Dietary restriction and lifespan: Lessons from invertebrate models.
TLDR
Current advances in understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster are reviewed.About:
This article is published in Ageing Research Reviews.The article was published on 2017-10-01 and is currently open access. It has received 252 citations till now.read more
Citations
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Facing up to the global challenges of ageing.
TL;DR: Interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health in humans.
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From discoveries in ageing research to therapeutics for healthy ageing
TL;DR: It is suggested that ageing research is entering a new era that has unique medical, commercial and societal implications, and that this era marks an inflection point in ageing research and for all biological research that affects the human healthspan.
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.
TL;DR: The breadth and depth of metabolic flexibility and its impact on health and disease are discussed and important advances in metabolic flexibility research are outlined and medical horizons and translational aspects are outlined.
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Autophagy and the cell biology of age-related disease
TL;DR: How the autophagy pathway restricts cellular damage and degeneration, and the impact of these functions towards tissue health and organismal lifespan is examined.
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Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
TL;DR: It is concluded that CR induces a surprising metabolic pattern characterized by periods of elevated FA synthesis alternating with periods of FA oxidation disproportionate to dietary FA intake, which may have implications for oxidative damage and disease risk.
References
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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
Andrea H. Brand,Norbert Perrimon +1 more
TL;DR: The GAL4 system, a system for targeted gene expression that allows the selective activation of any cloned gene in a wide variety of tissue- and cell-specific patterns, has been designed and used to expand the domain of embryonic expression of the homeobox protein even-skipped.
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Georg Dietzl,Doris Chen,Frank Schnorrer,Kuan-Chung Su,Yulia Barinova,Michaela Fellner,Michaela Fellner,Beate Gasser,Kaolin Kinsey,Kaolin Kinsey,Silvia Oppel,Silvia Oppel,Susanne Scheiblauer,Africa Couto,Vincent Marra,Krystyna Keleman,Krystyna Keleman,Barry J. Dickson,Barry J. Dickson +18 more
TL;DR: The generation and validation of a genome-wide library of Drosophila melanogaster RNAi transgenes, enabling the conditional inactivation of gene function in specific tissues of the intact organism and opening up the prospect of systematically analysing gene functions in any tissue and at any stage of the Drosophile lifespan.
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Extending Healthy Life Span-From Yeast to Humans
TL;DR: Dietary restriction and reduced activity of nutrient-sensing pathways may slow aging by similar mechanisms, which have been conserved during evolution, and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects.