Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TLDR
The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.Abstract:
Background Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure is complex. We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma with different susceptibility to ultraviolet light. Methods We compared genome-wide alterations in the number of copies of DNA and mutational status of BRAF and N-RAS in 126 melanomas from four groups in which the degree of exposure to ultraviolet light differs: 30 melanomas from skin with chronic sun-induced damage and 40 melanomas from skin without such damage; 36 melanomas from palms, soles, and subungual (acral) sites; and 20 mucosal melanomas. Results We found significant differences in the frequencies of regional changes in the number of copies of DNA and mutation frequencies in BRAF among the four groups of melanomas. Samples could be correctly classified into the four groups with 70 percent accuracy on the basis of the changes in the number of copies of...read more
Citations
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Journal ArticleDOI
Smoking, sun exposure, number of nevi and previous neoplasias are risk factors for melanoma in older patients (60 years and over).
Eduardo Nagore,L. Hueso,Rafael Botella-Estrada,A. Alfaro-Rubio,I Serna,JP Guallar,I González,I. Ribes,Carlos Guillén +8 more
TL;DR: This study focuses on risk factors which are more frequently associated to the over 60's age group, and aims to establish a causal relationship between these factors and malignant melanoma incidence.
Journal ArticleDOI
Melanomas of unknown primary frequently harbor TERT-promoter mutations.
Friederike Egberts,Sandra Krüger,Hans M. Behrens,Inka Bergner,Giorgios Papaspyrou,Jochen A. Werner,Ibrahim Alkatout,Jochen Haag,Axel Hauschild,Christoph Röcken +9 more
TL;DR: The aim of this study was to test the hypothesis that MUP and mucosal melanomas harbor different prevalences of TERT-promoter mutations, and no significant correlation was found between Tert-mutation and patient survival.
Journal ArticleDOI
Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007.
TL;DR: There is a latitude gradient for CMM on all body sites included in the present study, with 2-2.5 times higher incidence rates in the south, and the latitude gradients seem to be largest for the trunk.
Journal ArticleDOI
Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America
Carlos A. Castaneda,Carlos A. Torres-Cabala,Miluska Castillo,Valeria Villegas,Sandro Casavilca,Luis Cano,J. Sanchez,Jorge Dunstan,Gabriela Calderon,M. de la Cruz,Jose M. Cotrina,Henry L. Gomez,R. Galvez,Julio Abugattas +13 more
TL;DR: Lower TIL levels were associated with poor outcome and ALM, and survival analysis compared the outcome of ALM to whole group and extremity NALM was performed.
Journal ArticleDOI
Melanoma biomarkers: current status and vision for the future.
TL;DR: It is concluded that several biomarkers show promise in early studies; however, additional large-scale studies are warranted and cautious optimism is suggested for the field of melanoma biomarkers, which is expected to be translated into clinical practice over the next few years.
References
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Mutations of the BRAF gene in human cancer
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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
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Comparison of discrimination methods for the classification of tumors using gene expression data
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High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
TL;DR: The implementation of array CGH is demonstrated to be able to measure copy number with high precision in the human genome, and to analyse clinical specimens by obtaining new information on chromosome 20 aberrations in breast cancer.
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