Journal ArticleDOI
Distinct Sets of Genetic Alterations in Melanoma
John A. Curtin,Jane Fridlyand,Toshiro Kageshita,Hetal N. Patel,Klaus J. Busam,Heinz Kutzner,Kwang Hyun Cho,Setsuya Aiba,Eva B. Bröcker,Philip E. LeBoit,Daniel Pinkel,Boris C. Bastian +11 more
TLDR
The genetic alterations identified in melanoma at different sites and with different levels of sun exposure indicate that there are distinct genetic pathways in the development of melanoma and implicate CDK4 and CCND1 as independent oncogenes in melanomas without mutations in BRAF or N-RAS.Abstract:
Background Exposure to ultraviolet light is a major causative factor in melanoma, although the relationship between risk and exposure is complex. We hypothesized that the clinical heterogeneity is explained by genetically distinct types of melanoma with different susceptibility to ultraviolet light. Methods We compared genome-wide alterations in the number of copies of DNA and mutational status of BRAF and N-RAS in 126 melanomas from four groups in which the degree of exposure to ultraviolet light differs: 30 melanomas from skin with chronic sun-induced damage and 40 melanomas from skin without such damage; 36 melanomas from palms, soles, and subungual (acral) sites; and 20 mucosal melanomas. Results We found significant differences in the frequencies of regional changes in the number of copies of DNA and mutation frequencies in BRAF among the four groups of melanomas. Samples could be correctly classified into the four groups with 70 percent accuracy on the basis of the changes in the number of copies of...read more
Citations
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Journal ArticleDOI
Melanoma epidemiology, biology and prognosis.
TL;DR: This chapter considers each of these melanoma subtypes in turn, highlighting the differences in epidemiology, biology and prognosis between them.
Journal ArticleDOI
Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.
Richard J. Young,Kelly Waldeck,Claire Martin,Jung Hock Foo,Donald P. Cameron,Laura Kirby,Hongdo Do,Hongdo Do,Catherine Mitchell,Carleen Cullinane,Carleen Cullinane,Wendy Liu,Stephen B. Fox,Stephen B. Fox,Ken Dutton-Regester,Nicholas K. Hayward,Nicholas Jene,Alexander Dobrovic,Alexander Dobrovic,Alexander Dobrovic,Richard B. Pearson,Richard B. Pearson,James G. Christensen,Sophia Randolph,Grant A. McArthur,Grant A. McArthur,Karen E. Sheppard,Karen E. Sheppard +27 more
TL;DR: In 47 melanoma cell lines homozygous loss, methylation or mutation of CDKN2A gene or loss of protein (p16INK4A) predicted sensitivity to the CDK4/6 inhibitor PD0332991, while RB1 loss predicted resistance.
Journal ArticleDOI
NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G2-M Cell Cycle Progression
Maki Yamaura,Junji Mitsushita,Shuichi Furuta,Yukiko Kiniwa,Atsuko Ashida,Yasuhumi Goto,Wei H. Shang,Makoto Kubodera,Masayoshi Kato,Minoru Takata,Toshiaki Saida,Tohru Kamata +11 more
TL;DR: It is suggested that Nox4-generated ROS are required for transformation phenotype of melanoma cells and contribute to melanoma growth through regulation of G(2)-M cell cycle progression.
Incidence and Survival Patterns in the United States, 1986-2005
TL;DR: The authors examined incidence and survival patterns of acral lentiginous melanoma (ALM) in the United States and found that ALM is a rare melanoma subtype, although its proportion among all melanomas is higher in people of color.
Journal ArticleDOI
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions.
Antje Sucker,Fang Zhao,Natalia Pieper,Christina Heeke,Raffaela Maltaner,Nadine Stadtler,Birgit Real,Nicola Bielefeld,Sebastian Howe,Benjamin Weide,Ralf Gutzmer,Jochen Utikal,Carmen Loquai,Helen Gogas,Ludger Klein-Hitpass,Michael Zeschnigk,Astrid M. Westendorf,Mirko Trilling,Susanne Horn,Bastian Schilling,Bastian Schilling,Dirk Schadendorf,Klaus G. Griewank,Annette Paschen +23 more
TL;DR: The data demonstrate that JAK1/2 deficiency protects melanoma from anti-tumour IFNγ activity and results in T-cell-resistant HLA class I-negative lesions, which should be considered in therapeutic decision-making.
References
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Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
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