Dynamics and diversity in autophagy mechanisms: lessons from yeast
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TLDR
The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today.Abstract:
Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically distinct from conventional membrane traffic. The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today. Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy.read more
Citations
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Autophagic Cell Death and Cancer
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Mitochondria regulate autophagy by conserved signalling pathways
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Cysteine-generated sulfide in the cytosol negatively regulates autophagy and modulates the transcriptional profile in arabidopsis
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TL;DR: The results suggest that cysteine-generated sulfide in the cytosol negatively regulates autophagy and modulates the transcriptional profile of Arabidopsis, and sulfide is able to reverse ATG8 accumulation and lipidation, suggesting a general effect of sulfide on autophile regulation that is unrelated to sulfur or nitrogen limitation stress.
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The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.
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Viruses and the autophagy machinery.
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TL;DR: The complex interplay between autophagy and viral infection will be discussed and a newly recognized facet of innate and adaptive immunity against viral infection is identified.
References
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