Dynamics and diversity in autophagy mechanisms: lessons from yeast
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TLDR
The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today.Abstract:
Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically distinct from conventional membrane traffic. The discovery of autophagy in yeast and the genetic tractability of this organism have allowed us to identify genes that are responsible for this process, which has led to the explosive growth of this research field seen today. Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy.read more
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Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.
Huiwen Song,Xing Feng,Min Zhang,Xian Jin,Xiangdong Xu,Lin Wang,Xue Ding,Yunmei Luo,Fengqin Lin,Qin Wu,Guiyou Liang,Tian Yu,Qigong Liu,Zhiyong Zhang +13 more
TL;DR: Evidence is presented that the precise activity of ATG16L1 protein in hypoxia/reoxygenation (H/R)-treated cardiomyocytes is regulated by a balanced methylation and phosphorylation switch and highlights the importance of an ATG 16L1 phosphorylated-methylation switch in determining the fate of H/R-treated carduomyocytes.
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Vid30 is required for the association of Vid vesicles and actin patches in the vacuole import and degradation pathway
TL;DR: Vid30 plays a critical role for the association of Vid vesicle proteins Vid24 and Sec28 but not with the cargo protein FBPase, and it is suggested that Vid30 also has a role in the Vid pathway at a later step in a process that is mediated by the LisH and CTLH domains.
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PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation
Huaiping Zhu,Marc Foretz,Zhonglin Xie,Miao Zhang,Zhiren Zhu,Junjie Xing,J. Leclerc,Murielle Gaudry,Benoit Viollet,Ming-Hui Zou +9 more
TL;DR: It is concluded that PRKAA1-dependent autophagy-mediated clearance of damaged mitochondria is required for erythrocyte maturation and homeostasis and exacerbates oxidative stress in prkaa1−/− mice.
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Geldanamycin Reduces Aβ-Associated Anxiety and Depression, Concurrent with Autophagy Provocation
Nayereh Zare,Solmaz Khalifeh,Fariba Khodagholi,Shima Zareh Shahamati,Fereshteh Motamedi,Nader Maghsoudi +5 more
TL;DR: The behavioral analyses demonstrated that GA pretreatment can significantly decrease anxiety- and depression-like behaviors in Aβ-injected rats, and it was assumed that GA, at least in part, ameliorated A β-mediated anxiety and depression by inducing autophagy and improving antioxidant defense system.
Journal ArticleDOI
In search of new targets for retinal neuroprotection: is there a role for autophagy?
Rossella Russo,Laura Berliocchi,Annagrazia Adornetto,Diana Amantea,Carlo Nucci,Cristina Tassorelli,Luigi Antonio Morrone,Giacinto Bagetta,Maria Tiziana Corasaniti +8 more
TL;DR: There is the possibility that neuroprotection may be achieved by modulating autophagy, and this would be a promising approach as it could lead to the much-sought development of alternative therapeutic strategies to prevent visual loss in glaucoma.
References
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