Effects of the Reduced Form of Coenzyme Q10 (Ubiquinol) on Semen Parameters in Men with Idiopathic Infertility: a Double-Blind, Placebo Controlled, Randomized Study
TLDR
Ubiquinol was significantly effective in men with unexplained oligoasthenoteratozoospermia for improving sperm density, sperm motility and sperm morphology.About:
This article is published in The Journal of Urology.The article was published on 2012-08-01 and is currently open access. It has received 119 citations till now. The article focuses on the topics: Sperm motility & Sperm.read more
Citations
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Journal ArticleDOI
Antioxidants for male subfertility
Marian Showell,Rebecca Mackenzie-Proctor,Julie Brown,Anusch Yazdani,Marcin T Stankiewicz,Roger Hart +5 more
TL;DR: This Cochrane review aimed to evaluate the effectiveness and safety of oral supplementation with antioxidants for subfertile male partners in couples seeking fertility assistance with a placebo, no treatment or another antioxidant.
Journal ArticleDOI
Coenzyme Q10 Supplementation in Aging and Disease.
TL;DR: There is evidence that supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics and a need for further studies and clinical trials involving a greater number of participants undergoing longer treatments to assess the benefits of CoQ10 treatment in metabolic syndrome and diabetes, neurodegenerative disorders, kidney diseases, and human fertility.
Journal ArticleDOI
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Ashok Agarwal,Neel Parekh,Manesh Kumar Panner Selvam,Ralf Henkel,Ralf Henkel,Rupin Shah,Sheryl T. Homa,Ranjith Ramasamy,Edmund Y. Ko,Kelton Tremellen,Sandro C. Esteves,Sandro C. Esteves,Ahmad Majzoub,Ahmad Majzoub,Juan G. Alvarez,David K. Gardner,Channa N. Jayasena,Channa N. Jayasena,Jonathan Ramsay,Chak-Lam Cho,Ramadan A Saleh,Denny Sakkas,James M. Hotaling,Scott Lundy,Sarah C. Vij,Joel L. Marmar,Jaime Gosálvez,Edmund Sabanegh,Hyun Jun Park,Armand Zini,Parviz Kavoussi,Sava Micic,Ryan P. Smith,Gian Maria Busetto,Mustafa Emre Bakircioglu,Gerhard Haidl,Giancarlo Balercia,Nicolás Garrido Puchalt,Moncef Ben-Khalifa,Nicholas N. Tadros,Jackson Kirkman-Browne,Sergey I. Moskovtsev,Xuefeng Huang,Edson Borges,Daniel R. Franken,Natan Bar-Chama,Yoshiharu Morimoto,Kazuhisa Tomita,Vasan Satya Srini,Willem Ombelet,Elisabetta Baldi,Monica Muratori,Yasushi Yumura,Sandro La Vignera,Raghavender Kosgi,Marlon Martinez,Donald P. Evenson,Daniel Suslik Zylbersztejn,Matheus Roque,Marcello Cocuzza,Marcelo Vieira,Assaf Ben-Meir,Raoul Orvieto,Raoul Orvieto,Eliahu Levitas,Amir Wiser,Amir Wiser,Mohamed Arafa,Vineet Malhotra,Sijo Parekattil,Haitham Elbardisi,Luiz Carvalho,Rima Dada,Christophe Sifer,Pankaj Talwar,Ahmet Gudeloglu,Ahmed M A Mahmoud,Khaled Terras,Chadi Yazbeck,Bojanic Nebojsa,Damayanthi Durairajanayagam,Ajina Mounir,Linda G. Kahn,Saradha Baskaran,Rishma Pai,Donatella Paoli,Kristian Leisegang,Mohamed Reza Moein,Sonia Malik,Önder Yaman,Luna Samanta,Fouad Bayane,Sunil Jindal,Muammer Kendirci,Barış Altay,Dragoljub Perovic,Avi Harlev +96 more
TL;DR: Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants) and may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose.
Journal ArticleDOI
Utility of antioxidants during assisted reproductive techniques : an evidence based review
TL;DR: The current body of evidence as a whole suggests the need for further well-designed and larger scale randomized controlled studies, as well as research to minimize oxidative stress conditions in the clinical ART setting.
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Antioxidant supplements and semen parameters: An evidence based review
TL;DR: It was showed that antioxidant supplements, especially a combination of antioxidants such as vitamin C, vitamin E, and CoQ10 intake can effectively improve semen parameters in infertile men.
References
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Oxidative Decay of DNA
Kenneth B. Beckman,Bruce N. Ames +1 more
TL;DR: A proliferation of techniques has resulted in the confirmation of the early hypotheses and also delivered some surprises in the study of DNA oxidation, and some of the most interesting recent results are outlined.
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Biochemical Functions of Coenzyme Q10
TL;DR: Evidence for a function in redox control of cell signaling and gene expression is developing from studies on coenzyme Q stimulation of cell growth, inhibition of apoptosis, control of thiol groups, formation of hydrogen peroxide and control of membrane channels.
Journal ArticleDOI
Lipid Peroxidation and Human Sperm Motility: Protective Role of Vitamin E
TL;DR: Treatment of asthenospermic patients with oral Vitamin E significantly decreased the MDA concentration in spermatozoa and improved sperm motility, and nine of the 52 treated patients successfully impregnated their spouses.
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A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.
Andrea Lenzi,Paolo Sgrò,Pietro Salacone,Donatella Paoli,B. Gilio,Francesco Lombardo,Maria Santulli,Ashok Agarwal,Loredana Gandini +8 more
TL;DR: Combined treatment with l-carnitine and l-acetyl-c Carnitine in a controlled study of efficacy was effective in increasing sperm motility, especially in groups with lower baseline levels.
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Simultaneous Detection of Ubiquinol and Ubiquinone in Human Plasma as a Marker of Oxidative Stress
TL;DR: The ratio of ubiquinol to ubiquinone is determined to be about 95/5 in human plasma from healthy donors since this ratio has been suggested as a good marker of oxidative stress.