Emerging role of autophagy in kidney function, diseases and aging
Tobias B. Huber,Charles L. Edelstein,Björn Hartleben,Ken Inoki,Man Jiang,Daisuke Koya,Shinji Kume,Wilfred Lieberthal,Nicolas Pallet,Alejandro Quiroga,Kameswaran Ravichandran,Katalin Susztak,Sei Yoshida,Zheng Dong +13 more
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TLDR
Recent insights on the role of autophagy in kidney physiology and diseases are summarized alluding to possible novel intervention strategies for treating specific kidney disorders by modifying Autophagy.Abstract:
Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.read more
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References
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