EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
Citations
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Chen Wei,Chaogang Yang,Shuyi Wang,Dongdong Shi,Chunxiao Zhang,Xiaobin Lin,Qing Liu,Rongzhang Dou,Bin Xiong +8 more
TL;DR: It is indicated that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment.
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The multifaceted role of chromosomal instability in cancer and its microenvironment
TL;DR: These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.
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Contribution of Angiogenesis to Inflammation and Cancer.
Dolores Aguilar-Cazares,Rodolfo Chavez-Dominguez,Ángeles Carlos-Reyes,César López-Camarillo,Olga N Hernadez de la Cruz,Jose Sullivan Lopez-Gonzalez +5 more
TL;DR: The role of hypoxia as a mechanism that drives the acquisition of tumor hallmarks that make certain cancers more aggressive is discussed and some combinations of therapies that inhibit the angiogenesis process and that may be a successful strategy for cancer patients are indicated.
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miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization
Xiaobin Lin,Shuyi Wang,Min Sun,Min Sun,Chunxiao Zhang,Chen Wei,Chaogang Yang,Rongzhang Dou,Qing Liu,Bin Xiong +9 more
TL;DR: miR-195-5p may play a vital role in regulating NOTCH2-mediated tumor cell EMT, thereby affecting IL-4-related M2-like TAM polarization in CRC.
References
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Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5
Vittoria D'Esposito,Domenico Liguoro,Maria Rosaria Ambrosio,Francesca Collina,Monica Cantile,Rosa Spinelli,Gregory Alexander Raciti,Claudia Miele,Rossella Valentino,Pietro Campiglia,Michelino De Laurentiis,Maurizio Di Bonito,Gerardo Botti,Renato Franco,Francesco Beguinot,Pietro Formisano +15 more
TL;DR: In conclusion, inhibition of CCL5 in adipose microenvironment may represent a novel approach for the therapy of highly malignant TNBC.
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Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma.
TL;DR: It is concluded that IL-6 plays an important role through Stat3 in the EMT induction and can be a potential therapeutic target and biomarker for human cervical carcinoma.
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CXCR7 mediates TGFβ1-promoted EMT and tumor-initiating features in lung cancer
TL;DR: The results suggest that the TGFβ1-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future.
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High Infiltration of Tumor-Associated Macrophages Influences Poor Prognosis in Human Gastric Cancer Patients, Associates With the Phenomenon of EMT.
TL;DR: It is suggested that the high level of infiltration TAMs was associated with aggressive features of GC and is an independent poor prognostic factor in GC patients, and TAMs are associated with EMT induction in human GC tissues.
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The promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlying mechanisms.
TL;DR: It is suggested that IL-17 is positively correlated with the transformation of quiescent gastric CSCs into invasive gastricCSCs and that targeting IL- 17 may emerge as a possible novel therapeutic strategy for gastric cancer.