EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
Citations
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Chen Wei,Chaogang Yang,Shuyi Wang,Dongdong Shi,Chunxiao Zhang,Xiaobin Lin,Qing Liu,Rongzhang Dou,Bin Xiong +8 more
TL;DR: It is indicated that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment.
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The multifaceted role of chromosomal instability in cancer and its microenvironment
TL;DR: These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.
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Contribution of Angiogenesis to Inflammation and Cancer.
Dolores Aguilar-Cazares,Rodolfo Chavez-Dominguez,Ángeles Carlos-Reyes,César López-Camarillo,Olga N Hernadez de la Cruz,Jose Sullivan Lopez-Gonzalez +5 more
TL;DR: The role of hypoxia as a mechanism that drives the acquisition of tumor hallmarks that make certain cancers more aggressive is discussed and some combinations of therapies that inhibit the angiogenesis process and that may be a successful strategy for cancer patients are indicated.
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miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization
Xiaobin Lin,Shuyi Wang,Min Sun,Min Sun,Chunxiao Zhang,Chen Wei,Chaogang Yang,Rongzhang Dou,Qing Liu,Bin Xiong +9 more
TL;DR: miR-195-5p may play a vital role in regulating NOTCH2-mediated tumor cell EMT, thereby affecting IL-4-related M2-like TAM polarization in CRC.
References
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Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis
Long-Yun Ye,Wei Chen,Xueli Bai,Xingyuan Xu,Qi Zhang,Xue-Feng Xia,Xu Sun,Guogang Li,Qida Hu,Qihan Fu,Tingbo Liang +10 more
TL;DR: It is suggested that the HIF-1α/CCL20/IDO axis in hepatocellular carcinoma is important for accelerating tumor metastasis through both the induction of EMT and the establishment of an immunosuppressive tumor microenvironment, warranting further investigation into the therapeutic effects of blocking specific nodes of this signaling network.
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Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
TL;DR: A novel therapeutic approach may be provided to better battle PCa progression and metastasis at the castration resistant stage via the combination of targeting AR with siRNA and anti‐CCL2/CCR2‐STAT3 signalling.
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The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200
Muhammad Zaeem Noman,Bassam Janji,Abderemane Abdou,Meriem Hasmim,Stéphane Terry,Tuan Zea Tan,Fathia Mami-Chouaib,Jean Paul Thiery,Salem Chouaib +8 more
TL;DR: It is proposed that PD-L1 expression in E MT-activated breast cancer cells depends on the EMT-TF involved in EMT activation, and this results provide a novel preclinical rationale to explore EMT inhibitors as adjuvants to boost immunotherapeutic responses in subgroups of patients in whom malignant progression is driven by different EMTs.
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Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
TL;DR: The key principles of the circuits that control EMT under the influence of TGFβ are illustrated, which include the ability to perform two parallel molecular functions, and to mediate signaling crosstalk with other developmental signaling pathways.
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IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling.
Yasushi Shintani,Ayako Fujiwara,Toru Kimura,Tomohiro Kawamura,Soichiro Funaki,Masato Minami,Meinoshin Okumura +6 more
TL;DR: IL‐6 may contribute to maintenance of a paracrine loop that functions as part of the communication between CAFs and NSCLC cells, resulting in chemoresistance.