EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
Citations
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CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway
TL;DR: In this article , the authors explored underlying regulatory axis of circRNA PVT1 (circPVT1) in GC and found that the effect of miR-423-5p upregulation suppressed both cicRNA PVTs1 and SMAD3 in GC cells.
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Role of CXCR4 as a Prognostic Biomarker Associated With the Tumor Immune Microenvironment in Gastric Cancer.
TL;DR: In this article, CXC motif chemokine receptor 4 (CXCR4) was identified as a TME-related gene among thousands of differentially expressed genes (DEGs).
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Evaluation of Important Molecular Pathways and Candidate Diagnostic Biomarkers of Noninvasive to Invasive Stages in Gastric Cancer by In Silico Analysis.
Sara Tutunchi,Saeedeh Akhavan,Ahmad Bereimipour,Ahmad Bereimipour,Sayyed Mohammad Hossein Ghaderian +4 more
TL;DR: Wang et al. as mentioned in this paper used bioinformatics analysis to find appropriate diagnostic biomarkers in the extracellular matrix of noninvasive to invasive stages of gastric cancer patients.
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Pan-Cancer Analysis Reveals FH as a Potential Prognostic and Immunological Biomarker in Lung Adenocarcinoma
TL;DR: In this paper, the authors analyzed the prognostic value of FH and demonstrated the correlation between FH expression and tumor immunity, which indicated that FH is an immunotherapeutic target and a potential prognostic biomarker in lung adenocarcinoma (LUAD).
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Tumor accomplice: T cell exhaustion induced by chronic inflammation
TL;DR: The dynamic evolution of inflammation from acute to chronic in the process of tumor development, and its effect on T cells from activation to the promotion of exhaustion is summarized.
References
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Journal ArticleDOI
Monocyte chemoattractant protein-1 (MCP-1): an overview.
TL;DR: This review will discuss the biological processes and the structure and function of CCL2, one of the key chemokines that regulate migration and infiltration of monocytes/macrophages.
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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Catherine Uyttenhove,Luc Pilotte,Ivan Théate,Ivan Théate,Vincent Stroobant,Didier Colau,Nicolas Parmentier,Thierry Boon,Benoît Van den Eynde +8 more
TL;DR: It is shown that most human tumors constitutively express IDO, and that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice, suggesting that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor.
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng,Julienne L. Carstens,Jiha Kim,Matthew Scheible,Judith Kaye,Hikaru Sugimoto,Chia Chin Wu,Valerie S. LeBleu,Raghu Kalluri +8 more
TL;DR: This study functionally probes the role of EMT in PDAC by generating mouse models of PDAC with deletion of Snail or Twist, two key transcription factors responsible for EMT, and highlights the importance of combining EMT inhibition with chemotherapy for the treatment of pancreatic cancer.
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer,Anna Durrans,Sharrell Lee,Jianting Sheng,Fuhai Li,Stephen T. C. Wong,Hyejin Choi,Tina El Rayes,Seongho Ryu,Seongho Ryu,Juliane S. Troeger,Robert F. Schwabe,Linda T. Vahdat,Nasser K. Altorki,Vivek Mittal,Dingcheng Gao +15 more
TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.