EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
Citations
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Chen Wei,Chaogang Yang,Shuyi Wang,Dongdong Shi,Chunxiao Zhang,Xiaobin Lin,Qing Liu,Rongzhang Dou,Bin Xiong +8 more
TL;DR: It is indicated that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment.
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The multifaceted role of chromosomal instability in cancer and its microenvironment
TL;DR: These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.
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Contribution of Angiogenesis to Inflammation and Cancer.
Dolores Aguilar-Cazares,Rodolfo Chavez-Dominguez,Ángeles Carlos-Reyes,César López-Camarillo,Olga N Hernadez de la Cruz,Jose Sullivan Lopez-Gonzalez +5 more
TL;DR: The role of hypoxia as a mechanism that drives the acquisition of tumor hallmarks that make certain cancers more aggressive is discussed and some combinations of therapies that inhibit the angiogenesis process and that may be a successful strategy for cancer patients are indicated.
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miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization
Xiaobin Lin,Shuyi Wang,Min Sun,Min Sun,Chunxiao Zhang,Chen Wei,Chaogang Yang,Rongzhang Dou,Qing Liu,Bin Xiong +9 more
TL;DR: miR-195-5p may play a vital role in regulating NOTCH2-mediated tumor cell EMT, thereby affecting IL-4-related M2-like TAM polarization in CRC.
References
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TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment.
TL;DR: This review will explore the various effects of TGF-β, BMP, and activin signaling on stromal phenotypes known to associate with cancer progression, in the context of their tumor suppressive or promoting effects, as well as the molecular changes that these cytokines induce to influence stromAL phenotypes.
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Soluble factors regulated by epithelial–mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment
Meggy Suarez-Carmona,Morgane Bourcy,Julien Lesage,Natacha Leroi,Laïdya Syne,Silvia Blacher,Pascale Hubert,Charlotte Erpicum,Jean-Michel Foidart,Philippe Delvenne,Philippe Birembaut,Agnès Noël,Myriam Polette,Christine Gilles +13 more
TL;DR: The results show that EMT programmes trigger the expression of soluble mediators in cancer cells that stimulate angiogenesis and recruit myeloid cells in vivo, which might in turn favour cancer spread.
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IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib.
Romaine I. Fernando,Duane H. Hamilton,Charli Dominguez,Justin M. David,Kristen K. McCampbell,Claudia Palena +5 more
TL;DR: Generation of erlotinib-resistant lung cancer cells in vitro resulted in a phenotypic alteration reminiscent of an epithelial-mesenchymal transition (EMT) concomitant with a robust upregulation of the IL-8/IL-8R axis, which provides a rationale for the development of new therapeutic approaches involving blockade of IL- 8 signaling for the management of acquired resistance to EGFR inhibition in patients with lung cancer.
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Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells
TL;DR: TNF-α mediated regulation of claudin-1 and tumorigenic abilities of colon cancer cells is demonstrated and highlights a key role of deregulated claudIn-1 expression in inflammation-induced colorectal cancer growth and progression, through the regulation of the ERK and Src-signaling.
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MDSCs Mediate Angiogenesis and Predispose Canine Mammary Tumor Cells for Metastasis via IL-28/IL-28RA (IFN-λ) Signaling
TL;DR: It is shown for the first time that MDSCs secrete IL-28 (IFN-λ), which promotes angiogenesis, EMT, invasion and migration of tumor cells, which may constitute an interesting target for further therapies.