EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
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Signaling of Macrophages that Contours the Tumor Microenvironment for Promoting Cancer Development.
TL;DR: It is shown how macrophages induce such a response through abnormal cellular signaling and creating a cellular microenvironment conducive for tumor growth and metastasis, as well as the future outlook of this field.
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The Role of Aberrant Metabolism in Cancer: Insights Into the Interplay Between Cell Metabolic Reprogramming, Metabolic Syndrome, and Cancer.
Yina Yu,Liang Gong,Jun Ye +2 more
TL;DR: A comprehensive review of current knowledge on the relationship between aberrant metabolism and cancer is provided and the potential use of metabolism-targeting strategy for the treatment of cancer is discussed.
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Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Weihua Yu,Yongmei Tu,Zi Long,Jiangzheng Liu,Deqin Kong,J. Peng,Hao Wu,Gang Zheng,Jiuzhou Zhao,Yuhao Chen,Ruiqiang Li,Wenli Li,Chunxu Hai +12 more
TL;DR: Generally, cancer cells require an appropriate inflammatory microenvironment to support their growth, spread, and metastasis, and ROS may provide the necessary catalyst for inflammation-driven cancer.
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DGCR5 Promotes Gallbladder Cancer by Sponging MiR-3619-5p via MEK/ERK1/2 and JNK/p38 MAPK Pathways.
Shilei Liu,Bingfeng Chu,Chen Cai,Xiangsong Wu,Wen-Yan Yao,Zi-You Wu,Ziyi Yang,Fengnan Li,Yingbin Liu,Ping Dong,Wei Gong +10 more
TL;DR: It was uncovered in this study that DGCR5 exerts an oncogenic role by sponging miR-3619-5p and activating MEK/ERK1/2 and JNK/p38 MAPK pathways in GBC progression.
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TNFα and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer?
TL;DR: In this article, the authors show that the expression levels of TNF and TACE are significantly decreased in lung adenocarcinoma patients, while the TNFR1/TNFR2 balance is increased.
References
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Monocyte chemoattractant protein-1 (MCP-1): an overview.
TL;DR: This review will discuss the biological processes and the structure and function of CCL2, one of the key chemokines that regulate migration and infiltration of monocytes/macrophages.
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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Catherine Uyttenhove,Luc Pilotte,Ivan Théate,Ivan Théate,Vincent Stroobant,Didier Colau,Nicolas Parmentier,Thierry Boon,Benoît Van den Eynde +8 more
TL;DR: It is shown that most human tumors constitutively express IDO, and that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice, suggesting that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor.
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng,Julienne L. Carstens,Jiha Kim,Matthew Scheible,Judith Kaye,Hikaru Sugimoto,Chia Chin Wu,Valerie S. LeBleu,Raghu Kalluri +8 more
TL;DR: This study functionally probes the role of EMT in PDAC by generating mouse models of PDAC with deletion of Snail or Twist, two key transcription factors responsible for EMT, and highlights the importance of combining EMT inhibition with chemotherapy for the treatment of pancreatic cancer.
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer,Anna Durrans,Sharrell Lee,Jianting Sheng,Fuhai Li,Stephen T. C. Wong,Hyejin Choi,Tina El Rayes,Seongho Ryu,Seongho Ryu,Juliane S. Troeger,Robert F. Schwabe,Linda T. Vahdat,Nasser K. Altorki,Vivek Mittal,Dingcheng Gao +15 more
TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.