EMT and inflammation: inseparable actors of cancer progression
TLDR
The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.About:
This article is published in Molecular Oncology.The article was published on 2017-07-01 and is currently open access. It has received 368 citations till now. The article focuses on the topics: Epithelial–mesenchymal transition & Cancer cell.read more
Citations
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Book ChapterDOI
Inflammation and cancer
TL;DR: In this paper, the tumor-promoting role of immune and inflammatory responses and draw parallels between tumor-enhancing inflammation and normal functions of inflammation in tissue regeneration and host defense.
Journal ArticleDOI
A computational approach to unraveling TLR signaling in murine mammary carcinoma.
Chun Wai Liew,Tiffany Phuong,Carli B. Jones,Samantha E Evans,Justin Hoot,Kendall Weedling,DaMarcus A Ingram,Stacy Nganga,Robert A. Kurt +8 more
TL;DR: An agent-based model to simulate a signaling cascade allowed us to focus on the behavior of each class of agents independently of the other classes except when they were in physical contact, and found that these different cell types had distinctly different responses when exposed to two signals indicating that a more biologically relevant model and experimental system should address activation of multiple interconnected signaling cascades.
Journal ArticleDOI
Autologous cytokine-induced killer cell immunotherapy may improve overall survival in advanced malignant melanoma patients.
Yong Zhang,Yu'nan Zhu,Erjiang Zhao,He Xiaolei,Lingdi Zhao,Zibing Wang,Xiaomin Fu,Yalong Qi,Baozhen Ma,Yongping Song,Quanli Gao +10 more
TL;DR: It was found that the median survival time in CIK cell group was longer than the combined therapy group (21 vs 15 months, p = 0.07), and serum hemoglobin level as well as monocyte proportion and lymphocyte count were associated with patients' survival time.
Journal ArticleDOI
Sinapine Thiocyanate Inhibits the Proliferation and Mobility of Pancreatic Cancer Cells by Up-Regulating GADD45A
Jingya Wang,Zhirui Zeng,Shan Lei,Juanli Han,Shan Liao,Jinju Zhang,Lu Wang,Haiyang Li,Tengxiang Chen +8 more
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Journal ArticleDOI
The regulatory role of exosomal CagA and microRNAs derived from H. pylori-related gastric cancer cells on signaling pathways related to cancer development: a bioinformatics aspect
Nazila Bostanshirin,Ahmad Bereimipour,Mohammad ali Pahlevan Neshan,Mina Aghasafi,Romina Mehtararaghinia,Amin Ebrahimisadrabadi,Arsalan Jalili +6 more
TL;DR: The augmentation role of candidate genes in metastasis, migration, and angiogenesis in gastric cancer and also their regulatory role in pathogenesis and expansion of H. pylori-related Gastric cancer are evaluated to serve as an anti-cancer therapeutic agent.
References
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TL;DR: This review will discuss the biological processes and the structure and function of CCL2, one of the key chemokines that regulate migration and infiltration of monocytes/macrophages.
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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Catherine Uyttenhove,Luc Pilotte,Ivan Théate,Ivan Théate,Vincent Stroobant,Didier Colau,Nicolas Parmentier,Thierry Boon,Benoît Van den Eynde +8 more
TL;DR: It is shown that most human tumors constitutively express IDO, and that expression of IDO by immunogenic mouse tumor cells prevents their rejection by preimmunized mice, suggesting that the efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor.
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
Journal ArticleDOI
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Xiaofeng Zheng,Julienne L. Carstens,Jiha Kim,Matthew Scheible,Judith Kaye,Hikaru Sugimoto,Chia Chin Wu,Valerie S. LeBleu,Raghu Kalluri +8 more
TL;DR: This study functionally probes the role of EMT in PDAC by generating mouse models of PDAC with deletion of Snail or Twist, two key transcription factors responsible for EMT, and highlights the importance of combining EMT inhibition with chemotherapy for the treatment of pancreatic cancer.
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer,Anna Durrans,Sharrell Lee,Jianting Sheng,Fuhai Li,Stephen T. C. Wong,Hyejin Choi,Tina El Rayes,Seongho Ryu,Seongho Ryu,Juliane S. Troeger,Robert F. Schwabe,Linda T. Vahdat,Nasser K. Altorki,Vivek Mittal,Dingcheng Gao +15 more
TL;DR: The potential of an EMT-targeting strategy, in conjunction with conventional chemotherapies, for breast cancer treatment is suggested, using a mesenchymal-specific Cre-mediated fluorescent marker switch system in spontaneous breast-to-lung metastasis models.