Enhanced expression of transforming growth factor β1 in the rat brain after a localized cerebral injury
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TLDR
A role is suggested for TGF beta 1, not only in inflammation, but also in the tissue-specific glial scar formation that occurs in the CNS to help limit the pathogenesis associated with matrix deposition in the wound.About:
This article is published in Brain Research.The article was published on 1992-08-07 and is currently open access. It has received 235 citations till now. The article focuses on the topics: Glial scar & Lesion.read more
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Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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Molecular profile of reactive astrocytes—Implications for their role in neurologic disease
Michael Eddleston,Lennart Mucke +1 more
TL;DR: A summary of molecules whose levels of expression differentiate activated from resting astrocytes is provided and it becomes apparent that reactive astroCytes may benefit the injured nervous system by participating in diverse biological processes.
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What is immune privilege (not)
TL;DR: It is shown how immune privilege is far from absolute, and how it varies with age and brain region, as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment.
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Inflammatory response in acute traumatic brain injury: a double-edged sword.
TL;DR: Recent evidence supporting the dual, the beneficial, or the deleterious role of neuroinflammation after traumatic brain injury is reported.
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Secondary Cell Death and the Inflammatory Reaction After Dorsal Hemisection of the Rat Spinal Cord
Isabelle Dusart,Martin E. Schwab +1 more
TL;DR: The time course of the cellular reactions observed here suggests that secondary damage is not primarily due to destructive effects of neutrophils and macrophages, and the inflammatory process after spinal cord transection is qualitatively similar to that observed outside the CNS.
References
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Anita B. Roberts,Michael B. Sporn,Richard K. Assoian,J M Smith,Nanette S. Roche,Lalage M. Wakefield,U. Heine,Lance A. Liotta,Vincent Falanga,John H. Kehrl +9 more
TL;DR: Further data are obtained to support a role for TGF-beta as an intrinsic mediator of collagen formation: conditioned media obtained from activated human tonsillar T lymphocytes contain greatly elevated levels of T GF-beta compared tomedia obtained from unactivated lymphocytes.
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Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.
Ronald A. Ignotz,Joan Massagué +1 more
TL;DR: The results demonstrate a functional involvement of fibronectin in mediating cellular responses to TGFbeta, and suggest a model for TGF beta action based on the control of the extracellular matrix in target cells.
Journal ArticleDOI
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.
TL;DR: The results show that platelets contain a type beta transforming growth factor, which is distinct from platelet-derived growth factor and elicits 50% of its maximal biological response at concentrations less than 5 x 10(-12) M.
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Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
Dylan R. Edwards,G. Murphy,J. J. Reynolds,S. E. Whitham,A. J. P. Docherty,P. Angel,John K. Heath +6 more
TL;DR: The observations suggest that TGF‐beta exerts a selective effect on extracellular matrix deposition by modulating the action of other growth factors on metalloproteinase and TIMP expression.
Book
Peptide Growth Factors and Their Receptors
TL;DR: A comprehensive survey of the chemistry and biology of peptide growth factors is presented in this paper, where the peptides described here are of fundamental importance for understanding the behavior of all cells, and they will be of major importance in the practice of clinical medicine in the years to come.