Epidermal Permeability Barrier Defects and Barrier Repair Therapy in Atopic Dermatitis
Hae Jin Lee,Seung Hun Lee +1 more
TLDR
Recent advances in human and animal models of Atopic dermatitis are discussed, focusing on the defects of the epidermal permeability barrier, its immunologic role and barrier repair therapy in AD.Abstract:
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease perpetuated by gene-environmental interactions and which is characterized by genetic barrier defects and allergic inflammation. Recent studies demonstrate an important role for the epidermal permeability barrier in AD that is closely related to chronic immune activation in the skin during systemic allergic reactions. Moreover, acquired stressors (e.g., Staphylococcus aureus infection) to the skin barrier may also initiate inflammation in AD. Many studies involving patients with AD revealed that defective skin barriers combined with abnormal immune responses might contribute to the pathophysiology of AD, supporting the outside-inside hypothesis. In this review, we discuss the recent advances in human and animal models, focusing on the defects of the epidermal permeability barrier, its immunologic role and barrier repair therapy in AD.read more
Citations
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Book ChapterDOI
Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.
TL;DR: Some major changes in epidermal lipid biosynthesis in patients with AD and other related skin diseases are discussed, and how inflammation has a deteriorating effect on the SC lipids and SC biosynthesis.
Book ChapterDOI
Atopic Dermatitis: Pathophysiology
TL;DR: This chapter will discuss the multifaceted etiology of atopic dermatitis which will help to elucidate potential therapeutic targets and review existing treatment options and their interaction with the complex inflammatory and molecular triggers of atopy dermatitis.
Journal ArticleDOI
Significance of Skin Barrier Dysfunction in Atopic Dermatitis
Byung Eui Kim,Donald Y.M. Leung +1 more
TL;DR: Improved identification and characterization of AD phenotypes and endotypes are required to optimize the precision medicine approach to AD.
Journal ArticleDOI
Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march
Tali Czarnowicki,Tali Czarnowicki,James G. Krueger,James G. Krueger,Emma Guttman-Yassky,Emma Guttman-Yassky +5 more
TL;DR: Primary prophylaxis in children with established AD can be stratified into prevention of disease exacerbations by using proactive approaches (with either topical corticosteroids or topical calcineurin inhibitors) in mild AD cases or the prevention of other atopic disorders that will probably mandate systemic immunosuppression in severe AD cases.
Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery
Se Kyoo Jeong,Hyun Jeong Kim,Jong Kyung Youm,Sung Ku Ahn,Eung Ho Choi,Myung Hyun Sohn,Kyu-Earn Kim,Jeong Hee Hong,Dong Min Shin,Seung Hun Lee +9 more
TL;DR: In this article, the effects of both allergens on the epidermal barrier function as well as on the Epidermal calcium gradient were investigated, and it was shown that when applied on the barrier-disrupted site, increased protease activities in the epIDERmis and delayed barrier recovery and lamellar body secretion in murine skin.
References
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Journal ArticleDOI
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Peck Y. Ong,Takaaki Ohtake,Corinne Brandt,Ian Strickland,Mark Boguniewicz,Tomas Ganz,Richard L. Gallo,Donald Y.M. Leung +7 more
TL;DR: A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus.
Journal ArticleDOI
From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang,Randal J. Kaufman +1 more
TL;DR: New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases.
Journal ArticleDOI
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense
Yuping Lai,Richard L. Gallo +1 more
TL;DR: AMPs are multifunctional molecules that have a central role in infection and inflammation and complement their antimicrobial action and favor resolution of infection and repair of damaged epithelia.
Journal ArticleDOI
Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice.
Hiroshi Matsuda,Naohiro Watanabe,Gregory P. Geba,J Sperl,Masaoki Tsudzuki,Jun Hiroi,M Matsumoto,Hiroko Ushio,S Saito,Philip W. Askenase,Chisei Ra +10 more
TL;DR: It was found that skin lesions, which were clinically and histologically very similar to human AD, spontaneously appeared on the face, neck, ears and dorsal skin of inbred NC/Nga mice when they were raised in non-sterile (conventional) circumstances, but not under specific pathogen-free conditions.
Journal ArticleDOI
Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
Zoulfia Allakhverdi,Michael R. Comeau,Heidi K. Jessup,Bo-Rin Park Yoon,Avery W. Brewer,Suzanne Chartier,Nicole Paquette,Steven F. Ziegler,Marika Sarfati,Guy Delespesse +9 more
TL;DR: It is shown that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs) and is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.
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