Estrogen receptor-α signaling in post-natal mammary development and breast cancers
read more
Citations
The Mammary Gland: Basic Structure and Molecular Signaling during Development
Nuclear receptors in oral cancer-emerging players in tumorigenesis.
DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
Dynamic miRNA Landscape Links Mammary Gland Development to the Regulation of Milk Protein Expression in Mice
Segregation of nuclear and membrane-initiated actions of estrogen receptor using genetically modified animals and pharmacological tools
References
Mammary Stem Cells: Premise, Properties, and Perspectives
Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
ER-α36, a Novel Variant of ER-α, is Expressed in ER-positive and -negative Human Breast Carcinomas
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage
Related Papers (5)
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage
Frequently Asked Questions (20)
Q2. What have the authors stated for future works in "Estrogen receptor-α signaling in post-natal mammary development and breast cancers" ?
An important direction for future research is to further define the niche of ERα + luminal cells and identify niche signals regulating the development and homeostasis of this lineage.
Q3. What are the main pathways of ER signaling in mammary cells?
classical and nonclassical progesterone signaling pathways through nuclear and membrane receptors have been identified in mammary epithelial and cancer cells [153].
Q4. What is the role of ER in mammary morphogenesis?
In addition, non-genomic effects of ERα signaling that modulate intercellular communications participate in the regulation of mammary morphogenesis.
Q5. What is the role of estrogens in the development of the mammary gland?
In particular, estrogens induce the expression of progesterone receptor (PR) and prolactin receptor (PRLR) transcripts, highlighting the pivotal role of ERα signaling in the hormonal response of the developing mammary epithelium [136–138].
Q6. What was the effect of TET2 loss on mammary development?
TET2 loss led to a decreased expression of ERα, FOXA1 and GATA3 expression both at protein and mRNA levels that profoundly perturbed the luminal lineage commitment and the balance between the basal and the luminal lineages and thereby altered mammary development.
Q7. What is the effect of IGF1R on tumor formation in vivo?
overexpression of IGF1R in epithelial cells in mice leads to abnormal development of the ducts (hyperplasia) and tumor formation in vivo [239].
Q8. What is the effect of LOXL1 inhibition on tumor growth?
LOXL1 inhibition through a pan LOX inhibitor was found to reduce tumor growth and metastasis by human lobular cell lines injected intraductally.
Q9. What is the effect of RSPO1 on mammary side branching?
Using a luminal cell-specific Rspo1-deficient transgenic mouse model, the authors found that loss of RSPO1 resulted in reduced mammary side branching in adult virgin females, with a decreased ERα expression and signaling activity in luminal cells.
Q10. What is the way to detect ER46?
Western blot with antibodies directed against the C-terminal domain is the unique procedure to detect the ERα46 isoform since ERα46 and ERα66 share identical aminoacid sequences that cannot be distinguish by immunohistochemistry.
Q11. What is the status of ER in luminal cells?
Whether ERαhigh and ERαlow cells represent mature and progenitor cells or reflect a continuous gradient in ERα expression levels remains to be determined.
Q12. What are the main advantages of GEMMs?
GEMMs have contributed significantly to the field of breast cancer research and translational oncology, however, most of them develop ERα-negative mammary tumors [280].
Q13. What is the role of RIP140 in the development of the mammary gland?
RIP140 acts as a coregulator of ERα and is recruited to a number of its target gene promoters/ enhancers, such as Areg, Pgr, Ccnd1 and Stat5a.
Q14. What is the role of estrogen in the development of the pubertal duct?
Estrogens acts in concert with other growth factorsNumerous data have demonstrated that estrogens act in concert with growth factors and the cooperation between estrogens and growth hormone (GH) in governing pubertal development has been particularly studied.
Q15. What is the significance of ER loss in mammary cells?
the maintenance of early alveolar progenitors, potentially analogous to the so-called parity-identified mammary epithelial cells that express WAP and survive involution might be affected by ERα loss either directly or indirectly [202].
Q16. What is the role of ER in mammary gland development?
The data demonstrated that mutation of the palmitoylation site of ERα was necessary in promoting intercellular communications essential for mammary gland development.
Q17. What is the effect of PI3KCA on luminal ER + mamm?
PR + mammary tumors while its expression in the whole luminal population gave rise to luminal ERα + mammary tumors and basal-like ERα- PRtumors.
Q18. What is the role of FOXM1 in mammary luminal cell development?
The chromatin complex formed by ESR1, GATA3, and FOXA1 thus coordinately orchestrates mammary luminal lineage commitment and estrogen response.
Q19. What is the role of RSPO1 in the regulation of ER and Notch?
ERα and Notch1 expression in post-natal luminal cells is mutually exclusive [144], suggesting a negative cross-talk between Notch and ERα signaling.
Q20. What is the role of ER in the development of the mammary gland?
This model confirmed that estrogen-induced activation of ERα is crucial for the development of female reproductive tract and mammary gland [211].