Estrongenic steroid hormones in lung cancer.
TLDR
Current literature findings on the role of the ERs and the progesterone receptor (PR), as well CYP19 (aromatase), the rate-limiting enzyme in the synthesis of estrogen, in lung cancer are discussed.About:
This article is published in Seminars in Oncology.The article was published on 2014-02-01 and is currently open access. It has received 87 citations till now. The article focuses on the topics: Estrogen receptor & Aromatase.read more
Citations
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Cancer Risk in Women Using the Levonorgestrel-Releasing Intrauterine System in Finland
TL;DR: Using the levonorgestrel-releasing intrauterine system for treatment of menorrhagia during reproductive years was associated with a lower incidence of endometrial, ovarian, pancreatic, and lung cancers than expected and a higher than expected incidence of breast cancer.
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A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes.
Qing Zhou,Shuhua Xi +1 more
TL;DR: Current knowledge on the mechanisms of arsenic carcinogenesis is summarized and changes to the epigenome, metabolism of arsenic and epigenetic mechanisms, and cytotoxicity and regeneration proliferation are focused on to garner a broader perspective.
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Estrogen, Estrogen Receptor and Lung Cancer.
TL;DR: The current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen, the hormone replacement therapy and lung cancer risk and survival, and the mechanistic relationship between the ER and the epidermal growth factor receptor (EGFR), are reviewed.
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The Role of the Estrogen Pathway in the Tumor Microenvironment.
TL;DR: The interplay between estrogen and the tumor microenvironment and the clinical implications of endocrine therapy as a novel treatment strategy within immuno-oncology are reviewed.
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Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway
Kun-Shui Zhang,Hui-Qing Chen,Yi-Shen Chen,Kai-Feng Qiu,Xiao-bin Zheng,Guo-Cheng Li,Hai-Di Yang,Cui-Ju Wen +7 more
TL;DR: In this paper, the effects of BPA on the development of lung cancer were investigated and it was shown that BPA treatment significantly stimulated the in vitro migration and invasion of cells combing with morphological changes and up regulation of matrix metalloproteinase-2 (MMP-2) and MMP-9.
References
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Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
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ERβ: Identification and characterization of a novel human estrogen receptor
TL;DR: A novel estrogen receptor (hereinafter referred to as ERβ) was cloned using degenerate PCR primers and revealed that ERβ is expressed in human thymus, spleen, ovary and testis, and the level of transactivation by 17β‐estradiol is higher for ERα than for ERβ, which may reflect suboptimal conditions for ER β at thelevel of the ligand, responsive element or cellular context.
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Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
Shigeaki Kato,Hideki Endoh,Yoshikazu Masuhiro,Takuya Kitamoto,Shimami Uchiyama,Haruna Sasaki,Shoichi Masushige,Yukiko Gotoh,Eisuke Nishida,Hiroyuki Kawashima,Daniel Metzger,Pierre Chambon +11 more
TL;DR: The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1), which is modulated by the phosphorylated Ser118 through the Ras-MAPK cascade of the growth factor signaling pathways.
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A Randomized Trial Of Exemestane After Two To Three Years Of Tamoxifen Therapy In Postmenopausal Women With Primary Breast Cancer.
R. C. Coombes,Emma Hall,Lorna Gibson,Robert Paridaens,Jacek Jassem,Thierry Delozier,Stephen E. Jones,Isabel Alvarez,Gianfilippo Bertelli,Olaf Ortmann,Alan S. Coates,Emilio Bajetta,D. Dodwell,Robert E. Coleman,Lesley Fallowfield,Elizabeth Mickiewicz,Jens O. Andersen,Per Eystein Lønning,G. Cocconi,Alan L Stewart,N Stuart,Claire Snowdon,M. Carpentieri,Giorgio Massimini,Judith M Bliss +24 more
TL;DR: Exemestane therapy after two to three years ofTamoxifen therapy significantly improved disease-free survival as compared with the standard five years of tamoxIFen treatment.
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Identity of an Estrogen Membrane Receptor Coupled to a G Protein in Human Breast Cancer Cells
TL;DR: GPR30, an orphan receptor unrelated to nuclear estrogen receptors, has all the binding and signaling characteristics of a mER, and the identification of a second distinct class of GPCR-like steroid membrane receptors suggests a widespread role for GPCRs in nonclassical steroid hormone actions.