Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
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Journal ArticleDOI
Freezing of gait in Parkinson's disease is related to impaired motor switching during stepping
TL;DR: By contrasting motor and cognitive set switching within the same paradigm, the nature of set switching deficits associated with freezing of gait (FOG) is investigated.
Journal ArticleDOI
The Impact of Short and Long-Term Exercise on the Expression of Arc and AMPARs During Evolution of the 6-Hydroxy-Dopamine Animal Model of Parkinson's Disease.
TL;DR: Modifications in tyrosine hydroxylase expression may be relevant for corticostriatal circuits in PD, since the exercise-dependent plasticity can modulate GluAs expression and maybe neuronal excitability.
Journal ArticleDOI
Multidimensional apathy: evidence from neurodegenerative disease
Ratko Radakovic,Sharon Abrahams +1 more
TL;DR: It is demonstrated that overlapping elements exist, pointing towards commonalities in apathy subtypes, and can be subsumed under a unified Dimensional Apathy Framework: a triadic structure of Initiation, Executive and Emotional apathy.
Journal ArticleDOI
Relation between Resting State Front-Parietal EEG Coherence and Executive Function in Parkinson's Disease
Hiroko Teramoto,Akihiko Morita,Satoko Ninomiya,Takayoshi Akimoto,Hiroshi Shiota,Satoshi Kamei +5 more
TL;DR: The decrease in resting state functional connectivity between the frontal and parietal cortices especially in the left side is related to ED in PD.
Journal ArticleDOI
The relation of anxiety and cognition in Parkinson's disease.
TL;DR: The association of anxiety with a specific domain of executive function, set-shifting, in nondemented individuals with mild to moderate PD is supported, raising the possibility that treatment of anxiety may alleviate aspects of executive dysfunction in this population.
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