Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
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Journal ArticleDOI
A fronto–striato–subthalamic–pallidal network for goal-directed and habitual inhibition
TL;DR: It is suggested that imbalance between goal-directed and habitual action and inhibition contributes to some manifestations of Parkinson's disease, Tourette syndrome and obsessive–compulsive disorder and is proposed that basal ganglia surgery improves these disorders by restoring a functional balance between facilitation and inhibition.
Journal ArticleDOI
Parkinson's disease dementia: a neural networks perspective
TL;DR: It is argued that Parkinson’s disease dementia reflects dysfunction in seven distinct brain networks, with implications for therapeutic approaches.
Journal ArticleDOI
Techniques and Methods for Testing the Postural Function in Healthy and Pathological Subjects.
Thierry Paillard,Frédéric Noé +1 more
TL;DR: The aim of this review was to present and justify the different testing techniques and methods with their different quantitative and qualitative variables to make it possible to precisely evaluate each sensory, central, and motor component of the postural function according to the experiment protocol under consideration.
Journal ArticleDOI
Neuromechanical Principles Underlying Movement Modularity and Their Implications for Rehabilitation
Lena H. Ting,Lena H. Ting,Hillel J. Chiel,Randy D. Trumbower,Randy D. Trumbower,Jessica L. Allen,J. Lucas McKay,Madeleine E. Hackney,Trisha M. Kesar,Trisha M. Kesar +9 more
TL;DR: It is proposed that motor module organization is disrupted and may be improved by therapy in spinal cord injury, stroke, and Parkinson's disease.
Journal ArticleDOI
Network connectivity determines cortical thinning in early Parkinson’s disease progression
Yvonne H. C. Yau,Yashar Zeighami,Travis E. Baker,Travis E. Baker,Kevin Larcher,Uku Vainik,Uku Vainik,Mahsa Dadar,Vladimir S. Fonov,Patric Hagmann,Alessandra Griffa,Bratislav Misic,D.L. Collins,Alain Dagher +13 more
TL;DR: It is found that cortical thinning followed neural connectivity from a “disease reservoir” in Parkinson’s disease patients, suggesting that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cerebral cortex may herald the onset of cognitive impairment.
References
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Journal ArticleDOI
Cognitive complaints in Parkinson’s disease: its relationship with objective cognitive decline
Kathy Dujardin,Alain Duhamel,Marie Delliaux,Catherine Thomas-Antérion,Alain Destée,Luc Defebvre +5 more
TL;DR: Logistic regression incorporating the main demographical and clinical variables showed that the CCI score’s discriminant power was improved by adding age and the number of years in education to the predictive model, but theCCI does not enable more accurate screening for PD-associated dementia.
Journal ArticleDOI
The effects of Parkinson's disease on the capacity to generate information randomly.
TL;DR: Results showed that randomness decreased as generation rate increased in both groups, but with the patient group significantly impaired in comparison to controls, and the notion of a limited capacity response selector based on disruption to the Supervisory Attentional System is invoked.
Journal ArticleDOI
Cognitive impairment patterns in Parkinson’s disease with visual hallucinations
Feriha Özer,Hasan Meral,Lutfu Hanoglu,Oya Ozturk,Tuba Aydemir,Sibel Cetin,Birgül Atmaca,Raziye Tiras +7 more
TL;DR: In this article, the role of stage of disease, motor status and dopaminergic treatment in cognitive impairment of Parkinson's disease patients with visual hallucination (VH) and the presence of specific cognitive impairment patterns was investigated.
Book ChapterDOI
Differential executive control impairments in early Parkinson's disease.
TL;DR: The present investigation shows that PD is associated with a differential executive impairment pattern which is (partly) related to disease characteristics and affective variables.
Journal ArticleDOI
Investigation of Supervisory Attentional System Functions in Patients With Parkinson’s Disease Using the Hayling Task
TL;DR: In this paper, the authors explored executive dysfunction in Parkinson's disease by using the Hayling test (Burgess & Shallice, 1996) and verbal fluency tasks (VFTs).