Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
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Journal ArticleDOI
A computational model of prefrontal and striatal interactions in perceptual category learning
TL;DR: In this paper , a neurobiological model was proposed to describe the interactions between model-based and model-free decision systems in category learning, which was used to simulate published data from young adults, people with Parkinson's disease, and aged-matched older adults.
Journal ArticleDOI
Dissociation between function and manipulation in semantic representations of motor impaired subjects: A new test
Jorge Graneri,Sergio Dansilio,Macarena Martínez-Cuitiño,Lina Grasso,María Soledad Cantore,Luciana Brasca +5 more
TL;DR: This novel test was additionally administered to and evaluated in a group of Parkinson's disease patients and the Graded-Controlled Hub-and-Spoke model was used as a theoretical guide to interpret the results.
Language-Based Automatic Assessment of Cognitive and Communicative Functions Related to Parkinson’s Disease
TL;DR: The authors explored the use of natural language processing and machine learning for detecting evidence of Parkinson's disease from transcribed speech of subjects who are describing everyday tasks, and showed that these models can be used to predict cognitive abilities across all subjects.
Journal ArticleDOI
Effects of deep brain stimulation frequency on eye movements and cognitive control
Andre Zacharia,Diego Kaski,Walid Bouthour,Viswas Dayal,Matthieu Bereau,Philipp Mahlknecht,Dejan Georgiev,Julie Anne Peron,Thomas Foltynie,Ludvic Zrinzo,Marjan Jahanshahi,John C. Rothwell,Patricia Limousin +12 more
TL;DR: In this paper , the effects of 80 hz vs. 130 Hz frequency DBS on eye movements and executive control were compared to a healthy control group (n = 16), where all participants were tested twice in a double-blind manner.
Posted ContentDOI
NeuroEPO and cognitive function in Parkinsons disease in a randomized placebo-controlled and post-trial studies
Maria Luisa Bringas Vega,Li Shengnan,Ivonne Pedroso Ibañez,Emili Fernandez,Melissa Llano,D. Gonzalez,Teresita Rodriguez Obaya,Lílian Piron Ruiz,Iliana Sosa Testé,A. M. Rodriguez,Yaritza Leon,Faryal Razzaq,Marjan Jahanshahi,Pedro A. Valdes-Sosa +13 more
TL;DR: This preliminary results showed a positive effect of NeuroEPO on cognition in PD patients, with a strong positive influence of educational level and negative impact of age.
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