Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
More filters
Journal ArticleDOI
Age Effects on Spatiotemporal Dynamics of Response Inhibition: An MEG Study.
TL;DR: Age-related deficiencies in response inhibition were observed in both behavioral performance and neurophysiological measurement, and it was suggested that frontal recruitment plays a compensatory role in successful inhibition.
Journal ArticleDOI
The effect of dopaminergic medication on conflict adaptation in Parkinson's disease
TL;DR: The findings suggest that more sustained cognitive control processes may not be sensitive to dopamine overdose effects, and conflict adaptation in PD, which was unaffected by medication status, is suggested.
Journal ArticleDOI
Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease
TL;DR: In this paper , an MRI index capturing Alzheimer's disease-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort.
Journal ArticleDOI
Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.
Daniel Charissé,Guray Erus,Raymond Pomponio,Martin Gorges,Nele Schmidt,Christine Schneider,Inga Liepelt-Scarfone,Oliver Riedel,Kathrin Reetz,Jörg B. Schulz,Daniela Berg,Alexander Storch,Karsten Witt,Richard Dodel,Elke Kalbe,Jan Kassubek,Rüdiger Hilker-Roggendorf,Simon Baudrexel +17 more
TL;DR: In this article, an MRI index capturing Alzheimer's disease-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort.
Journal ArticleDOI
The Key Search Subtest of the Behavioural Assessment of the Dysexecutive Syndrome in Children (BADS-C) Instrument Reveals Impaired Planning Without External Constraints in Children With Neurofibromatosis Type 1.
Daria Riva,Chiara Vago,Alessandra Erbetta,Veronica Saletti,Silvia Esposito,Roberto Micheli,Sara Bulgheroni +6 more
TL;DR: The authors found that planning without external indications is impaired in children with neurofibromatosis type 1 (NF1) because they have to rely entirely on self-organization and monitoring; this study provides information for remediation programs designed to improve functioning in daily life.
References
More filters
Journal ArticleDOI
Studies of interference in serial verbal reactions.
Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Journal ArticleDOI
Validity of the Trail Making Test as an Indicator of Organic Brain Damage
Book ChapterDOI
Attention to action: willed and automatic control of behavior
Donald A. Norman,Tim Shallice +1 more
TL;DR: This chapter proposes a theoretical framework structured around the notion of a set of active schemas, organized according to the particular action sequences of which they are a part, awaiting the appropriate set of conditions so that they can become selected to control action.