Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
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Journal ArticleDOI
Lexical-semantic search related to side of onset and putamen volume in Parkinson's disease.
Daymond Wagner,Paul J. Eslinger,Nicholas W. Sterling,Guangwei Du,Eun Young Lee,Martin Styner,Mechelle M. Lewis,Xuemei Huang +7 more
TL;DR: Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left ( PD-L) lateralizing symptoms were compared to matched controls on lexical properties and correlated with striatal volumes segmented from T1-weighted brain MR images.
Journal ArticleDOI
Disruptions of cortico-kinematic interactions in Parkinson's disease.
John McLinden,Roohollah Jafari Deligani,Mohammadreza Abtahi,Umer Akbar,Kunal Mankodiya,Yalda Shahriari +5 more
TL;DR: In this paper, EEG and kinematic data were collected from seven healthy participants and eight diagnosed with Parkinson's disease during a set of self-paced finger tapping tasks to investigate between-group differences in the cortical activities associated with movement.
Book ChapterDOI
Cortico-Striatal, Cognitive-Motor Interactions Underlying Complex Movement Control Deficits
Aaron Kucinski,Martin Sarter +1 more
TL;DR: Using lesion models, this work elucidate how attentional control deficits and/or reduced motor vigor and impaired motor sequencing from striatal dopamine loss contribute to fall propensity in order to provide a detailed understanding of the cognitive-motor operations that guide complex movement.
Dissertation
Effects of cardiorespiratory exercise on motor skill learning and cognitive executive functions in Parkinson’s disease
TL;DR: Functional Magnetic Resonance Imaging was employed to assess the effect of a 3-month AET program on the neural correlates of implicit motor sequence learning (MSL) in individuals with Parkinson’s disease.
Journal ArticleDOI
A Psychometric Tool for Evaluating Executive Functions in Parkinson’s Disease
Francesca Borgnis,Francesca Baglio,Elisa Pedroli,Federica Rossetto,Marco Meloni,Giuseppe Riva,Pietro Cipresso +6 more
TL;DR: Overall, EXIT 360° appeared to be a usable, easy-to-learn, engaging, and innovative instrument for PD.
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Journal ArticleDOI
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Book ChapterDOI
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