Journal ArticleDOI
Executive dysfunction in Parkinson's disease: a review.
TLDR
This review discusses how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression.Abstract:
Executive dysfunction can be present from the early stages of Parkinson's disease (PD). It is characterized by deficits in internal control of attention, set shifting, planning, inhibitory control, dual task performance, and on a range of decision-making and social cognition tasks. Treatment with dopaminergic medication has variable effects on executive deficits, improving some, leaving some unchanged, and worsening others. In this review, we start by defining the specific nature of executive dysfunction in PD and describe suitable neuropsychological tests. We then discuss how executive deficits relate to pathology in specific territories of the basal ganglia, consider the impact of dopaminergic treatment on executive function (EF) in this context, and review the changes in EFs with disease progression. In later sections, we summarize correlates of executive dysfunction in PD with motor performance (e.g., postural instability, freezing of gait) and a variety of psychiatric (e.g., depression, apathy) and other clinical symptoms, and finally discuss the implications of these for the patients' daily life.read more
Citations
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Journal ArticleDOI
Opposite Effects of Visual Cueing During Writing-Like Movements of Different Amplitudes in Parkinson's Disease.
Evelien Nackaerts,Alice Nieuwboer,Sanne Broeder,Bouwien C. M. Smits-Engelsman,Stephan P. Swinnen,Wim Vandenberghe,Elke Heremans +6 more
TL;DR: The results illustrate that, unlike for gait, visual cueing for fine-motor tasks requires a differentiated approach, taking into account the possible increases of accuracy constraints imposed by cueing.
Journal ArticleDOI
Effect of Levodopa on Reward and Impulsivity in a Rat Model of Parkinson's Disease.
Miguel M. Carvalho,Filipa Lopes Campos,Mariana Marques,Carina Soares-Cunha,Nikolaos Kokras,Christina Dalla,Hugo Leite-Almeida,Nuno Sousa,António J. Salgado +8 more
TL;DR: In an animal model of PD with bilateral mesostriatal and mesocorticolimbic degeneration, LD leads to the development of impulsive behaviors, strengthening the association between DRT and DDS/ICD in PD.
Journal ArticleDOI
Apathy and noradrenaline: silent partners to mild cognitive impairment in Parkinson's disease?
TL;DR: The search for PD-MCI biomarkers has employed an array of neuroimaging techniques, but still yields divergent findings, due in part to MCI's broad definition, encompassing heterogeneous cognitive domains, only some of which are affected in Parkinson's disease.
Journal ArticleDOI
Impact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice
TL;DR: The data illustrate that BDNF signaling regulates cognitive control processes presumably by maintaining striatal dopamine-glutamate balance, and suggests aberrations inBDNF signaling may act as a common neurobiological substrate that accounts for executive dysfunction observed in multiple psychiatric conditions.
Journal ArticleDOI
Touchscreen-paradigm for mice reveals cross-species evidence for an antagonistic relationship of cognitive flexibility and stability.
S. Helene Richter,Anne S. Vogel,Kai Ueltzhöffer,Chiara Muzzillo,Miriam A. Vogt,Katja Lankisch,Diana J. N. Armbruster-Genç,Marco A. Riva,Christian J. Fiebach,Peter Gass,Barbara Vollmayr +10 more
TL;DR: Results support a dichotomy of cognitive flexibility and stability as predicted by the Dual State Theory and replicate critical aspects of the human paradigm, which indicates the translational potential of the testing procedure and supports the use of touchscreen procedures in preclinical animal research.
References
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