Extracellular microRNA: A new source of biomarkers
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TLDR
A brief overview of miRNA biogenesis and function, the identification and potential roles of circulating extracellular miRNAs, and the prospective uses of mi RNAs as clinical biomarkers are provided.Abstract:
MicroRNAs (miRNAs) are a recently discovered class of small, non-coding RNAs that regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in many cellular processes, including differentiation, neoplastic transformation, and cell replication and regeneration. Because of these regulatory roles, it is not surprising that aberrant miRNA expression has been implicated in several diseases. Recent studies have reported significant levels of miRNAs in serum and other body fluids, raising the possibility that circulating miRNAs could serve as useful clinical biomarkers. Here, we provide a brief overview of miRNA biogenesis and function, the identification and potential roles of circulating extracellular miRNAs, and the prospective uses of miRNAs as clinical biomarkers. Finally, we address several issues associated with the accurate measurement of miRNAs from biological samples.read more
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Journal ArticleDOI
Circulating MicroRNAs: Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease?
TL;DR: The nature of the stability of miRNAs that circulate in the bloodstream are discussed and the available evidence regarding the possible function of these circulating mi RNAs in distant cell-to-cell communication is discussed.
Journal ArticleDOI
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
Margaret Alexander,Ruozhen Hu,Marah C. Runtsch,Dominique Kagele,Timothy L. Mosbruger,Tanya Tolmachova,Miguel C. Seabra,June L. Round,Diane M. Ward,Ryan M. O'Connell +9 more
TL;DR: Findings provide strong evidence that endogenous microRNAs undergo a functional transfer between immune cells and constitute a mechanism of regulating the inflammatory response.
Journal ArticleDOI
Comparing the MicroRNA spectrum between serum and plasma.
TL;DR: The difference between serum and plasma miRNA concentration showed some associations with miRNA from platelets, which may indicate that the coagulation process may affect the spectrum of extracellular miRNA in blood.
Journal ArticleDOI
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
Carmen Elena Condrat,Dana Claudia Thompson,Madalina Gabriela Barbu,Oana Larisa Bugnar,Andreea Elena Boboc,Dragos Cretoiu,Nicolae Suciu,Sanda Maria Cretoiu,Silviu Cristian Voinea +8 more
TL;DR: There is promising evidence that in spite of the lack of standardized protocols regarding the use of miRNA in current clinical practice, they constitute a reliable tool for future use, and it is anticipated that miRNAs will become a routine approach in the development of personalized patient profiles, thus permitting more specific therapeutic interventions.
Journal ArticleDOI
MicroRNAome genome: a treasure for cancer diagnosis and therapy.
TL;DR: The authors explore current strategies in designing miRNA‐targeting therapeutics, as well as the associated challenges that research envisions to overcome, and introduce a new wave in molecular oncology translational research: the study of long noncoding RNAs.
References
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Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
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