Journal ArticleDOI
Free radicals and diabetes
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Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Effect of Ethanolic Extract of Bauhinia Monandra Leaf on the Liver of Alloxan Induced Diabetic Rats
Antidiabetic effect of aqueous extract of butea monosperma (LAM) Taub bark
TL;DR: In this article, the antidiabetic potential of Butea monosperma (Lam.) Taub has been investigated in the rats by treating with alloxan monohydrate (150 mg/kg b wt ;ip) and hydrocortisone (5mg/100gb wt; ip) respectively.
Effect of Diabetes on Endothelial Function
Keiko Naruse,George L. King +1 more
TL;DR: The Framingham Study, which surveyed longitudinally over 5000 patients with 18 years of follow-up, indicated that major clinical manifestations of CAD were increased in diabetic patients, especially in women.
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Evaluation of serum ferritin in in type II diabetes mellitus: a hospital based observational study from Dibrugarh, Assam, India -
TL;DR: Serum ferritin levels was significantly increased in diagnosed cases of type 2 diabetes mellitus and this increase may contribute to the pathogenesis of this disease as well as in the development of complications, indicating routine screening for serum ferrit in pre-diabetes and diabetic patients can be done to assess the body iron stores.
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Oxidative stress in the animal model: the possible protective role of milk serum protein
Nicola Traverso,Emanuela Balbis,Samir Giuseppe Sukkar,Anna Lisa Furfaro,Anna Massa Sacchi-Nemours,Claudia Ferrari,Stefania Patriarca,Damiano Cottalasso +7 more
TL;DR: Whey proteins (WP) are particularly rich in cysteine (cys) and in glutamine (glu) and therefore potentially capable of increasing the organism’s antioxidant defences, and it is thought that the principal mechanism which allows WPs to exert their properties is through the contribution of cys and glu, which is rich in these proteins and is used intra-cellularly for the synthesis of glutathione.
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Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.