Journal ArticleDOI
Free radicals and diabetes
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Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Effect of vitamin E treatment on tissue fatty acids and cholesterol content in experimental diabetes
TL;DR: The effects of 8 months of a pharmacological dose of vitamin E were studied on cholesterol content and fatty acid distribution in streptozotocin-diabetic rats under a controlled diet and induced a decrease of monounsaturated fatty acids and particularly palmitoleic acid.
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Screening for anti-diabetic activity of the ethanolic extract of Barleria cristata seeds
TL;DR: The present study aims to open new avenues for the improvement of medicinal uses of Barleria cristata L (Acanthaceae) for the selected area for diabetes and lays the foundation to study the active compounds of such anti-diabetic plants that are responsible for the hypoglycemic activities.
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Impaired synthesis is not the reason for decreased activity of extracellular superoxide dismutase in patients with diabetes.
Kazimierz Ciechanowski,Karolina Kędzierska,Edyta Gołembiewska,Krzysztof Safranow,Joanna Bober,Leszek Domański,Jacek Różański,Marek Myślak +7 more
TL;DR: The decrease of extracellular superoxide dismutase activity in diabetes develops due to excessive glycation but not due to impaired synthesis, therefore, appropriate glycemic control can lead to normalization of EC SOD activity.
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Effect of D-myo-inositol on platelet function and composition and on cataract development in streptozotocin-induced diabetic rats.
TL;DR: PP-56 appears to modulate fatty acid desaturases and aldose reductase in platelets and delay by a few weeks the development of cataract in this acute model of diabetes.
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Is serum ferritin high in patients with diabetic retinopathy? A controlled study.
TL;DR: Iron does not have a major role in the development of diabetes mellitus or diabetic retinopathy, and there was no correlation between HbA1c level and serum iron or ferritin levels between the 2 diabetic patients' groups.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.