Journal ArticleDOI
Free radicals and diabetes
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TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
Citations
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Journal ArticleDOI
Diabetes mellitus: role of free radicals and oxidative stress
TL;DR: Evidence of oxidative stress is a key process in the onset of diabetes, and Lipid per oxidation owing to free radical activity plays an important role in complications of diabetes.
Journal ArticleDOI
Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector.
Naoya Kishikawa,Kaname Ohyama,Junko Yao,Aoi Miyamoto,Takahiro Imazato,Yukitaka Ueki,Kenichiro Nakashima,Eisuke Maehata,Naotaka Kuroda +8 more
TL;DR: The results suggest that the measurement of antioxidant activity against different ROS may provide us with valuable information regarding the disease state and the evaluation of antioxidative activities against each ROS by the proposed method should be more informative to understand the antioxidative status of biological fluid.
Journal ArticleDOI
Correlation of Serum Ferritin with Components of Metabolic Synd rome and its Relationship with the Insulin Resistance in Men and Women
Boinapalli Sudhakar,Shah Rita M +1 more
TL;DR: It is concluded that hyperferritinaemia and iron overload may be the primary cause of insulin resistance and metabolic syndrome before overt type 2 diabetes mellitus.
DissertationDOI
Effects of grape pomace on metabolic syndrome: diabetes and obesity
TL;DR: This research project targeted on characterize the action of GPE in reducing postprandial hyperglycemia through inhibition of alpha-glucosidase, and provided molecular evidence toward understanding the mode action in preventing diabetes and obesity.
References
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Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
Journal ArticleDOI
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
Journal ArticleDOI
Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.