Journal ArticleDOI
Free radicals and diabetes
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TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
Citations
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BookDOI
Atherosclerosis, Hypertension and Diabetes
TL;DR: One of the books that can be recommended for new readers is atherosclerosis hypertension and diabetes, which is not kind of difficult book to read.
Journal ArticleDOI
Antihyperglycaemic, antioxidative activities of a formulated polyherbal drug MTEC (Modified) in streptozotocin-induced diabetic rat.
TL;DR: Results of the present study support the therapeutic potentiality of this polyherbal drug MTEC for the management of diabetes.
Book ChapterDOI
Part IX • Chapter 24 – Protection against free radical injury in the heart and cardiac performance
Journal ArticleDOI
Effect of methylglyoxal on glucose formation, drug oxidation and glutathione content in isolated murine hepatocytes
TL;DR: It is assumed that methylglyoxal has contrasting effects in hepatocytes, and can contribute to the disturbed metabolism under circumstances when the acetone production is elevated.
Journal ArticleDOI
MDL 29311. Antioxidant with marked lipid- and glucose-lowering activity in diabetic rats and mice
Marry B Johnson,Eric W Heineke,Barry L. Rhinehart,Matthew J. Sheetz,Roger L. Barnhart,Keith M. Robinson +5 more
TL;DR: A cross-over study indicated that MDL 29311 did not attenuate the diabetogenic action of ALX, but rather, directly lowered glucose and triglycerides, and merits additional investigation as a potential antidiabetic agent.
References
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Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
Journal ArticleDOI
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
Journal ArticleDOI
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
Journal ArticleDOI
Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.