Journal ArticleDOI
Free radicals and diabetes
Reads0
Chats0
TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
Citations
More filters
Antidiabetic activity of flower head petroleum ether extracts of sphaeranthus indicus Linn.
TL;DR: The present study proves the traditional claim of Bundelkhand region with regard to Sphaeranthus indicus for its anti-diabetic activity and lays the foundation to study the active compounds of such anti-Diabetic plants that are responsible for the hypoglycemic activities.
Journal ArticleDOI
Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes
TL;DR: In the CD rats that develop DM when fed HSD, the pancreas showed susceptibility to oxidative stress-induced injuries, and enhanced oxidative stress seems to play a role in the pathogenesis of DM in this strain.
Journal ArticleDOI
Antidiabetic effects of Eugenia jambolana in the streptozotocin-induced diabetic male albino rat
TL;DR: Investigation of the antidiabetic effect of the ethyl acetate fraction of the seed of Eugenia jambolana in streptozotocin-induced diabetic male albino rats shows a significant antihyperglycemic action in both short-term and long-term treatment schedules.
Journal ArticleDOI
Copper metabolism--a factor in gestational diabetes?
TL;DR: The results indicate that oxidative stress may have a role in gestational diabetes mellitus and that reduced concentrations of copper are not the cause of this stress.
Journal Article
Antioxidant effect of aqueous extract of sumac (Rhus coriaria L.) in the alloxan-induced diabetic rats.
TL;DR: The present study showed that Rhus coriaria could be effective in decreasing diabetic complication and this effect is attributed to the antioxidant activity of the plant.
References
More filters
Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
Journal ArticleDOI
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
Journal ArticleDOI
CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
Journal ArticleDOI
Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.