Journal ArticleDOI
Free radicals and diabetes
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TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Effect of Phaseolus vulgaris on circulatory antioxidants and lipids in rats with streptozotocin-induced diabetes.
TL;DR: Oral administration of an aqueous extract of P. vulgaris pods (PPEt, 200 mg/kg body weight) for 45 days significantly reduced the elevated blood glucose, serum triglycerides, free fatty acids, phospholipids, total cholesterol, very-low-density lipoprotein cholesterol, and low-density cholesterol in diabetic rats.
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Methylglyoxal toxicity in mammals
TL;DR: The effects of methylglyoxal in both in vivo and in vitro mammalian systems are reviewed and correlated with its interaction with macromolecules and the theories on the role of methyl Glyoxal and glyoxalases are discussed.
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The homeostasis model assessment-insulin resistance index is inversely associated with serum carotenoids in non-diabetic subjects.
Minoru Sugiura,Mieko Nakamura,Yoshinori Ikoma,Masamichi Yano,Kazunori Ogawa,Hikaru Matsumoto,Masaya Kato,Makoto Ohshima,Akihiko Nagao +8 more
TL;DR: The serum antioxidant carotenoids were inversely associated with HOMA-estimated insulin resistance in non-diabetic subjects, and in male subjects, an inverse association with the serum β-cryptoxanthin concentrations.
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Superoxide as a Messenger of Endothelial Function
Volker Ullrich,Markus Bachschmid +1 more
TL;DR: The author said that working at the Department of Biological Chemistry of the University of Konstanz during the period of 1999-2002 was at the same time instructional and fun, both of which being constantly upheld by his supervisor Prof. Volker Ullrich.
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Diabetic heart and kidney exhibit increased resistance to lipid peroxidation
TL;DR: It is concluded that diabetic tissues develop enhanced defense systems against oxidative stress and it is assumed that the lower levels of arachidonate contribute to their resistance to lipid peroxidation as well.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.