Journal ArticleDOI
Free radicals and diabetes
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TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Oxidant stress and skeletal muscle microvasculopathy in the metabolic syndrome.
TL;DR: The purpose of this review article is to present the different sources of oxidant stress within the setting of the metabolic syndrome, the available mechanism for attempts at regulation and the vascular outcomes associated with this condition.
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Garlic extract attenuates time-dependent changes in the reactivity of isolated aorta in streptozotocin-diabetic rats.
TL;DR: It is concluded that long-term administration of garlic extract can attenuate various functional alterations induced by STZ-diabetes in the vascular system of an insulin-dependent model of uncontrolled diabetes, and this may suggest a potential approach to future therapeutic strategies.
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Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro.
Lars Gille,Patricia Schott-Ohly,Nadira Friesen,Sabine Schulte im Walde,Natascha Udilova,Hans Nohl,Helga Gleichmann +6 more
TL;DR: It is concluded that streptozotocin-mediated hydroxyl radicals and generation of reactive oxygen species may be crucial effectors in beta-cell damage.
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Antioxidant enzymatic defense in salivary glands of streptozotocin-induced diabetic rats: a temporal study.
TL;DR: The results suggest that diabetes can cause alterations on the salivary glands and that PA and SM glands react differently when exposed to diabetes condition, but no impairment of antioxidant system was observed in the group whose diabetic condition had been induced 60 days earlier, herein named 60‐day group.
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Sod and GSH inhibit the high glucose-induced oxidative damage and the PDGF increased secretion in cultured human endothelial cells.
Francesco Curcio,I. Pegoraro,P. Dello Russo,Edmondo Falleti,Giuseppina Perrella,Antonio Ceriello +5 more
TL;DR: The effects of antioxidants on the high glucose-dependent oxidative cell damage and increased platelet-derived growth factor secretion have been investigated using cultured human endothelial cells and suggest that antioxidants may be a helpful therapeutic adjuvant to reduce the vascular complications of diabetes.
References
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.