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Free radicals and diabetes
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Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Итоги изучения патофизиологических последствий нарушения регуляции свободнорадикальных процессов: тупик или новый импульс?
TL;DR: The results of recent studies indicate that oxidatively modified LDL involved not only the primary injury to the vessel walls, but also provoked the development of endothelial dysfunction, so that once again raises the issue of the need for the use of antioxidants to prevent injuries in vascular walls.
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Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats
Nora Abdullah AlFaris,Ghedeir M. Alshammari,Muneer M. Alsayadi,Munirah A. AlFaris,Mohammed A. Yahya +4 more
TL;DR: Administration of Duvalia corderoyi led to significant ameliorative effects on the oxidative stress and histopathology of liver and kidney tissues of D. c orderoyi treated diabetic rats.
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Effects of chromium supplementation on oxidative Stress biomarkers
TL;DR: A systematic review and meta-analysis aimed to evaluate the effects of chromium supplementation on oxidative stress biomarkers such as superoxide dismutase (SOD), glutathione (GSH), peroxidase (GPX), malondialdehyde (MDA), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), catalase (CAT), nitric oxide (NO), and protein carbonyl as discussed by the authors .
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Pharmacognostic and hypoglycemic studies of Achyranthus aspera L.
TL;DR: It was concluded that EEA has hypoglycemic properties and it is recommended for the treatment of diabetes mellitus II.
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Study of serum copper and zinc in diabetic retinopathy and its correlation with glycemic status
TL;DR: There was statistically highly significant increase in serum copper levels in cases of retinopathy compared to controls, and Pearson's correlation was performed to establish the relationship between study variables.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.