Journal ArticleDOI
Free radicals and diabetes
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TLDR
Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1988-01-01. It has received 1136 citations till now. The article focuses on the topics: Streptozotocin & Diabetes mellitus.read more
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Relationship of Cellular Oxidant and Antioxidant Status with Disease Activity in Patients with Rheumatoid Arthritis
TL;DR: Bu çalışmamızdaki amaçlarımız RA hastalarında plazma ve özellikle eritrositlerdeki oksidan ve antioksidan statüyü araştırmak ve bu statünün hastalık aktivite indeksi (DAS) 28’e göre ılımlı, orta
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Lipid Lowering and Antioxidant Effects of Newly Synthesized 4-((Butylsulfinyl)methyl)-1,2-benzenediol (SMBD) in Diet-induced Hypercholesterolemic Rabbits
TL;DR: Raised antioxidant effect of SMBD results in significant prevention against hypercholesterolemia and significantly inhibited the increase of aortic intimal thickness by 36% via reducing of aORTic reactive oxygen species and cyclooxygenase-2 protein levels.
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Reoxygenation injury affects isolated islet response to fatty acid stimulation
TL;DR: It is found that pretreatment of freshly isolated islet islets with the antioxidant glutathione, as well as a 24-hour preculture of isolated islets under appropriate conditions, enhanced their sensitivity to fatty acid stimulation.
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Serum Malondialdehyde levels and lesion size in acute stroke
TL;DR: Serum malondialdehyde as a measure of lipid peroxidation is involved in the pathophysiology of these lesions and has definete corelation with the lesion size and no correlation was found between large and small lesion of thrombotic and haemorrhagic study group.
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Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
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Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
TL;DR: It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
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CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.
TL;DR: Pancreatic islets were found to belong to tissues with relatively little activity of the protective enzymes, and the deviation from other tissues in this respect is probably not large enough to explain the especially great susceptibility of islet cells to alloxan.
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Lipid peroxide level in plasma of diabetic patients.
TL;DR: The data obtained with a large sample of patients, and the relation between the lipid peroxide level and the different features of the disease are dealt with.