scispace - formally typeset
Open Access

Gene Ontology Consortium. The Gene Ontology (GO) database and informatics resource

TLDR
The Gene Ontology (GO) project provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences.
Abstract
The Gene Ontology (GO) project (http://www. geneontology.org/) provides structured, controlled vocabularies and classifications that cover several domains of molecular and cellular biology and are freely available for community use in the annotation of genes, gene products and sequences. Many model organism databases and genome annotation groups use the GO and contribute their annotation sets to the GO resource. The GO database integrates the vocabularies and contributed annotations and provides full access to this information in several formats. Members of the GO Consortium continually work collectively, involving outside experts as needed, to expand and update the GO vocabularies. The GO Web resource also provides access to extensive documentation about the GO project and links to applications that use GO data for functional analyses.

read more

Citations
More filters
Journal ArticleDOI

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

TL;DR: The distribution of the PcG proteins PC, E(Z and PSC and of trimethylation of histone H3 Lys27 (me3K27) in the D. melanogaster genome is determined and the role of these proteins in development, differentiation and disease is determined.
Journal ArticleDOI

The Mammalian Phenotype Ontology as a tool for annotating, analyzing and comparing phenotypic information.

TL;DR: The Mammalian Phenotype Ontology enables robust annotation of mammalian phenotypes in the context of mutations, quantitative trait loci and strains that are used as models of human biology and disease.
Journal ArticleDOI

The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation

TL;DR: What the original concepts were, what their present status is and how they may be expected to contribute to future system biology approaches are described.
Journal ArticleDOI

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

TL;DR: A compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states, indicating that immune specificity is important at many points in the signaling pathways of the immune response.
Related Papers (5)