Journal ArticleDOI
Generation of Superoxide Radical during Autoxidation of Hydroxylamine and an Assay for Superoxide Dismutase
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TLDR
Hydrogen peroxide stimulated the autoxidation and superoxide dismutase inhibited the hydrogen peroxide-induced oxidation, results which suggest the participation of hydrogenperoxide in autoxidated and in the generation of superoxide radical.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1978-02-01. It has received 1480 citations till now. The article focuses on the topics: Autoxidation & Reactive oxygen species.read more
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Expressions of oxidative stress-related genes and antioxidant enzyme activities in Mytilus galloprovincialis (Bivalvia, Mollusca) exposed to hypoxia
Seonock Woo,Vianney Denis,Hyokyung Won,Kyungsoon Shin,Gunsup Lee,Taek-Kyun Lee,Seungshic Yum +6 more
TL;DR: Results demonstrate the transcriptional stability and changes among several genes related to oxidative stress under oxygen-depletion conditions in M. galloprovincialis and provide useful information about the modulation of antioxidant enzyme activities induced by hypoxia in a marine animal.
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Neurotoxicity of dichlorvos: effect on antioxidant defense system in the rat central nervous system.
TL;DR: The results indicate that the enzymes SOD and catalase may enhance the disposal of potentially toxic radicals and the decrease in GSH levels may be a mechanism for the detoxification of dichlorvos in the brain.
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Protective effect of curcumin against chronic alcohol-induced cognitive deficits and neuroinflammation in the adult rat brain
Vinod Tiwari,Kanwaljit Chopra +1 more
TL;DR: Findings from the current study demonstrates the possible involvement of oxidative-nitrosative stress mediated cytokine release and inflammatory signaling in chronic alcohol-induced cognitive dysfunction and also suggests the effectiveness of curcumin in preventing cognitive deficits associated with chronic alcohol consumption.
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Chemopreventive potential of zinc in experimentally induced colon carcinogenesis
TL;DR: In this article, the authors evaluated the efficacy of zinc treatment on colonic antioxidant defense system and histoarchitecture in 1,2-dimethylhydrazine- (DMH) induced colon carcinogenesis in male Sprague-Dawley rats.
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Chemopreventive potential of zinc in experimentally induced colon carcinogenesis
TL;DR: Zinc has a positive beneficial effect against chemically induced colonic preneoplastic progression in rats induced by DMH, and tissue concentrations of zinc in the colon following DMH treatment are revealed to near normal levels.
References
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Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
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The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
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Inhibition of nitrite formation from hydroxylammoniumchloride: A simple assay for superoxide dismutase
Erich F. Elstner,Adelheid Heupel +1 more
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The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: Clostridial and spinach ferredoxins, reduced enzymatically by the action of ferredoxin-TPN+ oxidoreductase, have been shown to carry out the univalent reduction of oxygen.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.