Journal ArticleDOI
Generation of Superoxide Radical during Autoxidation of Hydroxylamine and an Assay for Superoxide Dismutase
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TLDR
Hydrogen peroxide stimulated the autoxidation and superoxide dismutase inhibited the hydrogen peroxide-induced oxidation, results which suggest the participation of hydrogenperoxide in autoxidated and in the generation of superoxide radical.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1978-02-01. It has received 1480 citations till now. The article focuses on the topics: Autoxidation & Reactive oxygen species.read more
Citations
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Renoprotective effect of Spirulina fusiformis on cisplatin-induced oxidative stress and renal dysfunction in rats.
TL;DR: The results of the present study clearly demonstrate the pivotal role of reactive oxygen species and their relation to renal dysfunction and point to the therapeutic potential of Spirulina fusiformis in cisplatin-induced nephrotoxicity.
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Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice.
Shashank Singh,Ruchika Bhatia,Pragyanshu Khare,Shikha Sharma,Sivasubramanian Rajarammohan,Mahendra Bishnoi,Sanjay Kumar Bhadada,Shyam S. Sharma,Jaspreet Kaur,Kanthi Kiran Kondepudi +9 more
TL;DR: Bifidobacterium supplementation inhibited the abundances of pathobionts such as Haemophilus, Klebsiella and Lachnospira there by conferring protection and lower levels of Lipocalin-2, TNF-α, IL-1β and IL-6 and improved SCFA levels were observed in BifidOBacterium supplemented mice relative to DSS counterparts.
Journal ArticleDOI
Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.
TL;DR: Naringenin showed potent neuroprotective effect in depression comparable to the fluoxetine by restoring alterations in kynurenine pathway via its antioxidant and anti‐inflammatory potential.
Journal ArticleDOI
Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson's disease.
TL;DR: The neuroprotective effect of GP may be attributed to increased antioxidation, as manifested by significantly increased glutathione content and enhanced superoxide dismutase activity in the substantia nigra.
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Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing losses.
Esperanza Bas,T. R. Van De Water,Chhavi Gupta,John Dinh,Ly Vu,F Martinez-Soriano,JM Láinez,Jaime Marco +7 more
TL;DR: This study investigated the otoprotective efficacy of dexamethasone (DXM), melatonin (MLT) and tacrolimus (TCR) in gentamicin (GM)‐treated animals and cultures.
References
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Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
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The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
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Inhibition of nitrite formation from hydroxylammoniumchloride: A simple assay for superoxide dismutase
Erich F. Elstner,Adelheid Heupel +1 more
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The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: Clostridial and spinach ferredoxins, reduced enzymatically by the action of ferredoxin-TPN+ oxidoreductase, have been shown to carry out the univalent reduction of oxygen.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.