Journal ArticleDOI
Generation of Superoxide Radical during Autoxidation of Hydroxylamine and an Assay for Superoxide Dismutase
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TLDR
Hydrogen peroxide stimulated the autoxidation and superoxide dismutase inhibited the hydrogen peroxide-induced oxidation, results which suggest the participation of hydrogenperoxide in autoxidated and in the generation of superoxide radical.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1978-02-01. It has received 1480 citations till now. The article focuses on the topics: Autoxidation & Reactive oxygen species.read more
Citations
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Effect of dopamine receptor 1 on apoptosis of cultured neonatal rat cardiomyocytes in simulated ischaemia/reperfusion.
Hongzhu Li,Li-Ping Han,Chun-ming Jiang,Hong Li,Yajun Zhao,Jun Gao,Yan Lin,Shu-xia Ma,Ye Tian,Baofeng Yang,Changqing Xu +10 more
TL;DR: DR1 activation is involved in the apoptosis of cultured neonatal rat cardiomyocytes in simulated ischaemia/reperfusion through the mitochondrial and death receptor pathways.
Journal ArticleDOI
Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol.
TL;DR: The data reveal that sesamol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation, and apoptosis and thus exerts a marked renoprotective effect.
Journal ArticleDOI
Integrative application of cyanobacteria and antioxidants improves common bean performance under saline conditions
TL;DR: In this article, the impacts of CB, with or without glutathione (GSH) and ascorbic acid (AsA) and their combinations on morphological, physiological, metabolic, and enzymatic activity status in common bean plant grown on salt stressed soil were investigated.
Journal ArticleDOI
Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease rat model.
Rajan Kumar,Rakesh Kumar,Navneet Khurana,Sachin Kumar Singh,Shelly Khurana,Surajpal Verma,Neha Sharma,Bhupinder Kapoor,Manish Vyas,Rubiya Khursheed,Ankit Awasthi,Jaskiran Kaur,Leander Corrie +12 more
TL;DR: This study suggests that SNEDDS improved the oral bioavailability of FS which further helped in improving its neuroprotective activity in rat model of PD and suggests the potential use of FS-SNEDDS in effective management of PD condition.
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The potential therapeutic effects of the gut microbiome manipulation by synbiotic containing-Lactobacillus plantarum on neuropsychological performance of diabetic rats.
TL;DR: The data demonstrated that administration of L. plantarum and inulin could improve gut dysbiosis and oxidative stress status and confirm that there is a beneficial therapeutic potential of supplements, especially symbiotic.
References
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Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.
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The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
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Inhibition of nitrite formation from hydroxylammoniumchloride: A simple assay for superoxide dismutase
Erich F. Elstner,Adelheid Heupel +1 more
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The Generation of Superoxide Radical during the Autoxidation of Hemoglobin
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: Clostridial and spinach ferredoxins, reduced enzymatically by the action of ferredoxin-TPN+ oxidoreductase, have been shown to carry out the univalent reduction of oxygen.
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The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.