Journal ArticleDOI
Global malaria mortality between 1980 and 2010: a systematic analysis
Christopher J L Murray,Lisa C. Rosenfeld,Stephen S Lim,Kathryn G. Andrews,Kyle J Foreman,Diana Haring,Nancy Fullman,Mohsen Naghavi,Rafael Lozano,Alan D. Lopez +9 more
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TLDR
The findings show that the malaria mortality burden is larger than previously estimated, especially in adults, and there has been a rapid decrease in malaria mortality in Africa because of the scaling up of control activities supported by international donors.About:
This article is published in The Lancet.The article was published on 2012-02-04. It has received 1440 citations till now. The article focuses on the topics: Malaria & Child mortality.read more
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Plasmodium Products Contribute to Severe Malarial Anemia by Inhibiting Erythropoietin-Induced Proliferation of Erythroid Precursors
Neeta Thawani,Mifong Tam,Marie-Josée Bellemare,D. Scott Bohle,Martin Olivier,J. Brian de Souza,J. Brian de Souza,Mary M. Stevenson +7 more
TL;DR: The findings suggest that parasite factors, including Hz, contribute to severe malarial anemia by suppressing Epo-induced proliferation of erythroid precursors.
Journal ArticleDOI
Photonic Monitoring of Atmospheric and Aquatic Fauna
TL;DR: In this paper, the emerging field of optics and laser-based monitoring of flying fauna is reviewed with an emphasis on remote sensing based on pulsed and contineous wave (CW) lidar systems, and how they complement existing radar techniques.
Journal ArticleDOI
Impact Evaluation of Seasonal Malaria Chemoprevention under Routine Program Implementation: A Quasi-Experimental Study in Burkina Faso.
Thomas Druetz,Nicolas Corneau-Tremblay,Tieba Millogo,Seni Kouanda,Antarou Ly,Abel Bicaba,Slim Haddad +6 more
TL;DR: This is the first time that malaria can be reported as hypo-endemic in a sub-Sahelian setting in Burkina Faso, and SMC has great potential, and along with other interventions, it could contribute to approaching the threshold where elimination strategies will be envisioned in BurkINA Faso.
Journal ArticleDOI
Falciparum Malaria as an Emerging Cause of Fever in Adults Living in Gabon, Central Africa
Marielle K. Bouyou-Akotet,Christelle L. Offouga,Denise Patricia Mawili-Mboumba,Laurence Essola,Blondel Madoungou,Maryvonne Kombila +5 more
TL;DR: Almost half of adults consulting for fever in two health centres of the urban city of Libreville have malaria; the use of insecticide-treated bed nets, the screening, and the treatment of individuals with P. falciparum microscopic and submicroscopic asymptomatic infection or clinical malaria should be emphasized to reduce the transmission.
Journal ArticleDOI
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Stephen N. Hewitt,David M. Dranow,Benjamin G. Horst,Jan Abendroth,Barbara Forte,Irene Hallyburton,Chimed Jansen,Beatriz Baragaña,Ryan Choi,Kasey Rivas,Matthew A. Hulverson,Mitchell Dumais,Thomas E. Edwards,Donald D. Lorimer,Alan H. Fairlamb,David W. Gray,Kevin D. Read,Adele M. Lehane,Kiaran Kirk,Peter J. Myler,Peter J. Myler,Amy K. Wernimont,Chris Walpole,Robin Stacy,Lynn K. Barrett,Ian H. Gilbert,Wesley C. Van Voorhis +26 more
TL;DR: Two new inhibitors of PfProRS that bind outside the active site are identified, demonstrating this class of compounds could overcome the toxicity related to HsProRS inhibition by halofuginone and its analogues.
References
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Book
The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Global, regional, and national causes of child mortality in 2008: a systematic analysis
Robert E. Black,Simon Cousens,Hope L. Johnson,Joy E Lawn,Igor Rudan,Diego G. Bassani,Prabhat Jha,Harry Campbell,Christa L Fischer Walker,Richard E Cibulskis,Thomas P. Eisele,Li Liu,Colin Mathers +12 more
TL;DR: New estimates for 2008 of the major causes of death in children younger than 5 years in 193 countries are reported to help to focus national programmes and donor assistance.
Journal ArticleDOI
The global distribution of clinical episodes of Plasmodium falciparum malaria
TL;DR: It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
Journal ArticleDOI
Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5.
Margaret C. Hogan,Margaret C. Hogan,Kyle J Foreman,Mohsen Naghavi,Stephanie Y. Ahn,Mengru Wang,Susanna M Makela,Alan D. Lopez,Rafael Lozano,Christopher J L Murray +9 more
TL;DR: Although only 23 countries are on track to achieve a 75% decrease in MMR by 2015, countries such as Egypt, China, Ecuador, and Bolivia have been achieving accelerated progress and substantial, albeit varied, progress has been made towards MDG 5.
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