Journal ArticleDOI
Global malaria mortality between 1980 and 2010: a systematic analysis
Christopher J L Murray,Lisa C. Rosenfeld,Stephen S Lim,Kathryn G. Andrews,Kyle J Foreman,Diana Haring,Nancy Fullman,Mohsen Naghavi,Rafael Lozano,Alan D. Lopez +9 more
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TLDR
The findings show that the malaria mortality burden is larger than previously estimated, especially in adults, and there has been a rapid decrease in malaria mortality in Africa because of the scaling up of control activities supported by international donors.About:
This article is published in The Lancet.The article was published on 2012-02-04. It has received 1440 citations till now. The article focuses on the topics: Malaria & Child mortality.read more
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Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum
TL;DR: Positive proliferation assays showed that these PMO conjugates have potent antimalarial activity, blocking early development, maturation, and replication of the parasite.
Journal ArticleDOI
Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold
TL;DR: A unique fungi-derived prefractionated library was screened against a chloroquine-sensitive Plasmodium falciparum line (3D7) using a radiometric growth inhibition assay and a library fraction derived from a Cortinarius species displayed promising antimalarial activity.
Journal ArticleDOI
Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences.
Masanori Yagi,Gilles Bang,Takahiro Tougan,Nirianne Marie Q. Palacpac,Nobuko Arisue,Taiki Aoshi,Yoshitsugu Matsumoto,Ken Ishii,Thomas G. Egwang,Pierre Druilhe,Toshihiro Horii +10 more
TL;DR: It is suggested that strict tertiary structure of SE36 epitopes is not required to elicit protective antibodies in naturally immune Ugandan adults and protein structure predictions and structural analysis of SE 36 indicated that N-terminal regions possessing inhibitory epitopes are intrinsically unstructured.
Journal ArticleDOI
Identification and Functional Analysis of the Primary Pantothenate Transporter, PfPAT, of the Human Malaria Parasite Plasmodium falciparum
Yoann Augagneur,Lise Jaubert,Matthieu Schiavoni,Niseema Pachikara,Aprajita Garg,Sahar Usmani-Brown,Donna Wesolowski,Skye Zeller,Abhisek Ghosal,Emmanuel Cornillot,Hamid M. Said,Priti Kumar,Sidney Altman,Choukri Ben Mamoun +13 more
TL;DR: The essential function of PfPAT and its ability to deliver both pantothenate and fenpropimorph makes it an attractive target for the development and delivery of new classes of antimalarial drugs.
Journal ArticleDOI
Anopheles gambiae Circumsporozoite Protein–Binding Protein Facilitates Plasmodium Infection of Mosquito Salivary Glands
Jiuling Wang,Yue Zhang,Yue Zhang,Yang O. Zhao,Yang O. Zhao,Michelle W.M. Li,Michelle W.M. Li,Lili Zhang,Srdjan M. Dragovic,Srdjan M. Dragovic,Nabil M. Abraham,Nabil M. Abraham,Erol Fikrig,Erol Fikrig +13 more
TL;DR: In vivo bioassays showed that mosquitoes that were fed blood with CSPBP antibody displayed a 25% and 90% reduction in the parasite load in infected salivary glands 14 and 18 days after the blood meal, respectively, suggesting that CSP BP is important for the infection of the mosquitoSalivary gland by Plasmodium organisms and that blocking C SPBP can interfere with the PlasModium life cycle.
References
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The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Global, regional, and national causes of child mortality in 2008: a systematic analysis
Robert E. Black,Simon Cousens,Hope L. Johnson,Joy E Lawn,Igor Rudan,Diego G. Bassani,Prabhat Jha,Harry Campbell,Christa L Fischer Walker,Richard E Cibulskis,Thomas P. Eisele,Li Liu,Colin Mathers +12 more
TL;DR: New estimates for 2008 of the major causes of death in children younger than 5 years in 193 countries are reported to help to focus national programmes and donor assistance.
Journal ArticleDOI
The global distribution of clinical episodes of Plasmodium falciparum malaria
TL;DR: It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
Journal ArticleDOI
Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5.
Margaret C. Hogan,Margaret C. Hogan,Kyle J Foreman,Mohsen Naghavi,Stephanie Y. Ahn,Mengru Wang,Susanna M Makela,Alan D. Lopez,Rafael Lozano,Christopher J L Murray +9 more
TL;DR: Although only 23 countries are on track to achieve a 75% decrease in MMR by 2015, countries such as Egypt, China, Ecuador, and Bolivia have been achieving accelerated progress and substantial, albeit varied, progress has been made towards MDG 5.
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