Journal ArticleDOI
Global malaria mortality between 1980 and 2010: a systematic analysis
Christopher J L Murray,Lisa C. Rosenfeld,Stephen S Lim,Kathryn G. Andrews,Kyle J Foreman,Diana Haring,Nancy Fullman,Mohsen Naghavi,Rafael Lozano,Alan D. Lopez +9 more
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TLDR
The findings show that the malaria mortality burden is larger than previously estimated, especially in adults, and there has been a rapid decrease in malaria mortality in Africa because of the scaling up of control activities supported by international donors.About:
This article is published in The Lancet.The article was published on 2012-02-04. It has received 1440 citations till now. The article focuses on the topics: Malaria & Child mortality.read more
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Insecticide resistance in Anopheles mosquitoes : additional obstacles in the battle against malaria.
TL;DR: This synthetic review supplies an overview of all of the modes of resistance developed by Anopheles mosquitoes against these human actions, and recommends a thorough adjustment of the use of the various means of control.
Journal ArticleDOI
Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.
Ana S. Ressurreição,Daniel Gonçalves,Ana R. Sitoe,Inês S. Albuquerque,Jiri Gut,Ana Góis,Lídia Gonçalves,Maria Rosário Bronze,Thomas Hänscheid,Giancarlo A. Biagini,Philip J. Rosenthal,Miguel Prudêncio,Paul M. O'Neill,Maria M. Mota,Francisca Lopes,Rui Moreira +15 more
TL;DR: These efforts to optimize quinolon-4(1H)-imines as dual-stage antiplasmodial agents endowed with chemical and metabolic stability are reported, which constitute excellent starting points for further lead optimization asDual-stage antimalarials.
Journal ArticleDOI
Determination of protein subcellular localization in apicomplexan parasites
Ben J. Woodcroft,Ben J. Woodcroft,Paul J. McMillan,Chaitali Dekiwadia,Leann Tilley,Stuart A. Ralph +5 more
TL;DR: The toolkit for establishing subcellular locations of apicomplexan proteins is becoming more extensive and specialized, and here is a review of developments in this technology.
Journal ArticleDOI
The impact of HIV on presentation and outcome of bacterial sepsis and other causes of acute febrile illness in Gabon
Michaëla A. M. Huson,Michaëla A. M. Huson,Rachel Kalkman,Rachel Kalkman,Sebastiaan M. Stolp,Sebastiaan M. Stolp,Saskia Janssen,Saskia Janssen,Abraham S. Alabi,Justin O. Beyeme,Tom van der Poll,Martin P. Grobusch,Martin P. Grobusch +12 more
TL;DR: The findings illustrate the impact of HIV co-infection on the burden of sepsis, malaria and tuberculosis in Gabon, as well as the need to scale up HIV counseling, testing and treatment.
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Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria.
TL;DR: The results show the pivotal mechanisms of AT1R-induced harmful phenotype of Plasmodium-specific CD8+ T cells during blood-stage malaria.
References
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The global burden of disease: a comprehensive assessment of mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020.
TL;DR: This is the first in a planned series of 10 volumes that will attempt to "summarize epidemiological knowledge about all major conditions and most risk factors" and use historical trends in main determinants to project mortality and disease burden forward to 2020.
Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Journal ArticleDOI
Global, regional, and national causes of child mortality in 2008: a systematic analysis
Robert E. Black,Simon Cousens,Hope L. Johnson,Joy E Lawn,Igor Rudan,Diego G. Bassani,Prabhat Jha,Harry Campbell,Christa L Fischer Walker,Richard E Cibulskis,Thomas P. Eisele,Li Liu,Colin Mathers +12 more
TL;DR: New estimates for 2008 of the major causes of death in children younger than 5 years in 193 countries are reported to help to focus national programmes and donor assistance.
Journal ArticleDOI
The global distribution of clinical episodes of Plasmodium falciparum malaria
TL;DR: It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
Journal ArticleDOI
Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5.
Margaret C. Hogan,Margaret C. Hogan,Kyle J Foreman,Mohsen Naghavi,Stephanie Y. Ahn,Mengru Wang,Susanna M Makela,Alan D. Lopez,Rafael Lozano,Christopher J L Murray +9 more
TL;DR: Although only 23 countries are on track to achieve a 75% decrease in MMR by 2015, countries such as Egypt, China, Ecuador, and Bolivia have been achieving accelerated progress and substantial, albeit varied, progress has been made towards MDG 5.
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