Journal ArticleDOI
Global trends in neglected tropical disease control and elimination: impact on child health
TLDR
The current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%.Abstract:
The neglected tropical diseases (NTDs) are a group of 17 lesser known chronic infections which predominantly affect poor and disenfranchised communities. There are a number of NTDs that cause significant global morbidity in children, including the three major soil transmitted helminth (STH) infections (ascariasis, trichuriasis and hookworm infection), schistosomiasis and trachoma. These NTDs, together with lymphatic filariasis and onchocerciasis, are currently being targeted for global control and elimination through mass drug administration (MDA) campaigns. They represent the most common NTDs and share significant geographical overlap. Additionally, many individuals are polyparasitised with more than a single NTD. Integrated NTD control and elimination MDA programmes offer safe and efficacious treatments for all seven NTDs. However, the current global level of MDA coverage for the leading childhood NTDs, that is, STH infections, schistosomiasis and trachoma, remains well under 50%. Limiting factors for global coverage include insufficient global financial support, drug donation capacity of pharmaceutical companies and targeting school age children to the exclusion of other age groups in need of treatment, such as preschool age children. There is also a need for development of novel prevention and treatment modalities, such as next-generation small molecule drugs and vaccines. Efforts are underway to harness the momentum of a 2012 London Declaration on NTDs and a 2013 World Health Assembly (WHA) resolution as a means to control or in some cases eliminate by 2020 these NTDs that affect children worldwide.read more
Citations
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Journal ArticleDOI
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk,Yifu Li,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Miguel Verbitsky,David Fasel,Sneh Lata,Sindhuri Prakash,Samantha Shapiro,Clara Fischman,Holly J. Snyder,Gerald B. Appel,Claudia Izzi,Battista Fabio Viola,Nadia Dallera,Lucia Del Vecchio,Cristina Barlassina,Erika Salvi,Francesca Bertinetto,Antonio Amoroso,Silvana Savoldi,Marcella Rocchietti,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Maurizio Salvadori,Pietro Ravani,Riccardo Magistroni,Gian Marco Ghiggeri,Gianluca Caridi,Monica Bodria,Francesca Lugani,Landino Allegri,Marco Delsante,Mariarosa Maiorana,Andrea Magnano,Giovanni M. Frascà,Emanuela Boer,Giuliano Boscutti,Claudio Ponticelli,Renzo Mignani,Carmelita Marcantoni,Domenico Di Landro,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Silvana Chicca,Marco Galliani,Maddalena Gigante,Loreto Gesualdo,Pasquale Zamboli,Giovanni Giorgio Battaglia,Maurizio Garozzo,Dita Maixnerova,Vladimir Tesar,Frank Eitner,Thomas Rauen,Jürgen Floege,Tibor Kovács,Judit Nagy,Krzysztof Mucha,Leszek Pączek,Marcin Zaniew,Małgorzata Mizerska-Wasiak,Maria Roszkowska-Blaim,Krzysztof Pawlaczyk,Daniel P. Gale,Jonathan Barratt,Lise Thibaudin,François Berthoux,Guillaume Canaud,Anne Boland,Marie Metzger,Ulf Panzer,Hitoshi Suzuki,Shin Goto,Ichiei Narita,Yasar Caliskan,Jingyuan Xie,Ping Hou,Nan Chen,Hong Zhang,Robert J. Wyatt,Jan Novak,Bruce A. Julian,John Feehally,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi +91 more
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.
Journal ArticleDOI
New developments in the genetics, pathogenesis, and therapy of IgA nephropathy.
Riccardo Magistroni,Riccardo Magistroni,Vivette D. D'Agati,Gerald B. Appel,Krzysztof Kiryluk +4 more
TL;DR: The “Intestinal Immune Network for IgA Production” emerged as one of the new targets for potential therapeutic intervention and is placed in the context of the multi-hit pathogenesis model and existing knowledge of IgA immunobiology.
Journal ArticleDOI
Emerging and Reemerging Neglected Tropical Diseases: a Review of Key Characteristics, Risk Factors, and the Policy and Innovation Environment
TL;DR: This review sets out to identify emerging and reemerging neglected tropical diseases and explore the policy and innovation environment that could hamper or enable control efforts and raise awareness and guide potential approaches to addressing this global health concern.
Journal ArticleDOI
Prevention and control of schistosomiasis: a current perspective
TL;DR: Integrated control, targeting the life cycle, is the only approach that will lead to sustainability and future elimination of Schistosomiasis.
Journal ArticleDOI
Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections
Bin Zhan,Coreen M. Beaumier,Neima Briggs,Kathryn M. Jones,Brian Keegan,Maria Elena Bottazzi,Peter J. Hotez +6 more
TL;DR: A five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.
References
More filters
Journal ArticleDOI
Global estimates of visual impairment: 2010.
TL;DR: It is indicated that visual impairment in 2010 is a major health issue that is unequally distributed among the WHO regions; the preventable causes are as high as 80% of the total global burden.
Journal ArticleDOI
Worms: Identifying Impacts on Education and Health in the Presence of Treatment Externalities
Edward Miguel,Michael Kremer +1 more
TL;DR: In this article, the authors evaluate a Kenyan project in which school-based mass treatment with deworming drugs was randomly phased into schools, rather than to individuals, allowing estimation of overall program effects.
Journal ArticleDOI
Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk
TL;DR: It is concluded that the development and management of water resources is an important risk factor for schistosomiasis, and hence strategies to mitigate negative effects should become integral parts in the planning, implementation, and operation of future water projects.
Journal ArticleDOI
Control of Neglected Tropical Diseases
Peter J. Hotez,David H. Molyneux,Alan Fenwick,Jacob Kumaresan,Sonia Ehrlich Sachs,Jeffrey D. Sachs,Lorenzo Savioli +6 more
TL;DR: In addition to malaria, tuberculosis, and human immunodeficiency virus infection, several other infectious diseases are associated with substantial morbidity and mortality as discussed by the authors, in particular 13 tropical diseases that cause disabilities such as blindness and heart failure.
Journal ArticleDOI
Soil-transmitted helminth infections: updating the global picture.
Nilanthi de Silva,Simon Brooker,Peter J. Hotez,Antonio Montresor,Dirk Engels,Lorenzo Savioli +5 more
TL;DR: Global estimates of soil-transmitted helminth infections are brought up to date, some interesting new trends are revealed and the future for control is discussed.
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