Gut Microbiome and Metabolites in Patients with NAFLD and after Bariatric Surgery: A Comprehensive Review.
TLDR
In this article, the authors provide an overview of the gut microbiome composition and related metabolites in individuals with non-alcoholic fatty liver disease and after bariatric surgery and demonstrate the clinical effects of such surgery on NAFLD.Abstract:
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing, as are other manifestations of metabolic syndrome such as obesity and type 2 diabetes. NAFLD is currently the number one cause of chronic liver disease worldwide. The pathophysiology of NAFLD and disease progression is poorly understood. A potential contributing role for gut microbiome and metabolites in NAFLD is proposed. Currently, bariatric surgery is an effective therapy to prevent the progression of NAFLD and other manifestations of metabolic syndrome such as obesity and type 2 diabetes. This review provides an overview of gut microbiome composition and related metabolites in individuals with NAFLD and after bariatric surgery. Causality remains to be proven. Furthermore, the clinical effects of bariatric surgery on NAFLD are illustrated. Whether the gut microbiome and metabolites contribute to the metabolic improvement and improvement of NAFLD seen after bariatric surgery has not yet been proven. Future microbiome and metabolome research is necessary for elucidating the pathophysiology and underlying metabolic pathways and phenotypes and providing better methods for diagnostics, prognostics and surveillance to optimize clinical care.read more
Citations
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The Role of Gut Microbiota and Its Produced Metabolites in Obesity, Dyslipidemia, Adipocyte Dysfunction, and Its Interventions.
TL;DR: In this article, the role of the gut microbiota metabolites in the development of dyslipidemia and alterations in lipid metabolism was discussed and the therapeutic potential of these metabolites was pointed out.
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Regulation of body weight: Lessons learned from bariatric surgery
Vance L. Albaugh,Yanlin He,Heike Münzberg,Christopher D. Morrison,Sangho Yu,Hans-Rudolf Berthoud +5 more
TL;DR: In this article , the authors evaluate the existing evidence for specific molecular and inter-organ signaling pathways that play major roles in bariatric surgery-induced weight loss and metabolic benefits, with a focus on Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), in both humans and rodents.
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Recent advances of gut microbiota in chronic kidney disease patients
TL;DR: Treatment with prebiotics, probiotics and natural products can attenuate CKD through improving dysbiosis of gut microbiota, indicating a novel intervention strategy in patients with CKD.
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Gut microbiome and microbial metabolites in NAFLD and after bariatric surgery: Correlation and causality
TL;DR: Characteristics of the gut microbiome in patients with NAFLD before and after BS are summarized and existing evidence about the underlying mechanisms of the Gut microbiome is accumulated.
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Aqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics.
Emma J. Robinson,Matthew C. Taddeo,Xin Chu,Weixing Shi,Craig Wood,Christopher J. Still,Virginia Rovnyak,David Rovnyak +7 more
TL;DR: In this article, a targeted 1H-NMR study of serum, combined with clinical variables, detected and localized biomarkers to stages of NAFLD in morbidly obese females.
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TL;DR: Bariatric surgery for severe obesity is associated with long-term weight loss and decreased overall mortality.
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