High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
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TLDR
The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.About:
This article is published in Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 252 citations till now. The article focuses on the topics: Fructokinase & Steatohepatitis.read more
Citations
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Journal ArticleDOI
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes.
María Cecilia Castro,Hernán Gonzalo Villagarcía,Guillermo Raúl Schinella,María Laura Massa,Flavio Francini +4 more
TL;DR: In this article , the effects of exendin-4 and des-fluoro-sitagliptin (dipeptidyl peptidase-4 inhibitor) on hepatic disturbances were evaluated in prediabetic rats.
Posted ContentDOI
Early exposure to high-fat diet impairs central and peripheral metabolic function: Impacts on cognition and mitochondrial function
Wembley R. Vilela,Paula Maria Quaglio Bellozi,Victor L. Picolo,Bruna Neves Cavadas,Keila Valentina Silva Marques,Louise Tavares Garcia Pereira,Angélica Amorim Amato,Kelly Grace Magalhães,Márcia Renata Mortari,Jair Trapé Goulart,Andreza Fabro de Bem +10 more
TL;DR: The results indicate that the introduction of a HFD early in life has a detrimental impact on bioenergetic and mitochondrial function of tissues with metabolic and thermogenic activities, which is likely related to hippocampal metabolic changes and cognitive impairment.
Journal ArticleDOI
Moderate Exercise Training Combined With a High-Fat and Sucrose Diet Protects Pancreatic Islet Function in Male C57BL/6J Mice
Katherine M. A. Veras,Camila Ferraz Lucena,Julia Goedcke,Fabiana S. Evangelista,Angelo Rafael Carpinelli,Carla Roberta de Oliveira Carvalho +5 more
TL;DR: Exercise training may slow down and/or prevent adverse metabolic effects associated with consuming a westernized diet in mice consuming a high-fat and sucrose diet, and improve glucose tolerance, body mass, insulin sensitivity and GSIS.
Journal ArticleDOI
Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK)
Fernando E. García-Arroyo,Guillermo Gonzaga-Sánchez,Alejandro Silva-Palacios,Francisco-Javier Roldán,María Lilia Loredo-Mendoza,Yamnia Quetzal Álvarez-Álvarez,Edilia Tapia,Horacio Osorio-Alonso,Abraham S. Arellano-Buendía,José L. Sánchez-Gloria,Miguel A. Lanaspa,Richard J. Johnson,Laura G. Sánchez-Lozada +12 more
TL;DR: In this article , the authors tested whether diet-induced metabolic syndrome causes heart disease associated with increased fructose content and metabolism and whether it can be prevented with a fructokinase inhibitor (osthole).
Dissertation
The Dynamic Nature of the POMC Neuron Landscape, and the Impact of POMC Peptides and Body Composition States in Motivated Feeding
TL;DR: To test whether glutamatergic POMC neurons serve a distinct role in maintaining energy homeostasis, activated Pomc expression Cre-dependently in Vglut2-expressing neurons of mice with conditionally silenced Pomc alleles, indicating that a subpopulation of Pomc neurons must express both neuronal markers.
References
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Journal ArticleDOI
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Xiaosen Ouyang,Pietro Cirillo,Yuri Y. Sautin,Shannon J. McCall,James L. Bruchette,Anna Mae Diehl,Richard J. Johnson,Manal F. Abdelmalek +7 more
TL;DR: The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity.
Journal ArticleDOI
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
Gianfranco Pagano,Giovanni Pacini,Giovanni Musso,Roberto Gambino,Fabio Mecca,Nadia Depetris,Maurizio Cassader,Ezio David,Paolo Cavallo-Perin,Mario Rizzetto +9 more
TL;DR: Hyperinsulinemia and insulin resistance occur frequently in patients with NASH; these conditions do not stem from a reduced hepatic insulin extraction but from an enhanced pancreatic insulin secretion compensatory to reduced insulin sensitivity.
Journal ArticleDOI
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
TL;DR: Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.
Journal ArticleDOI
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
TL;DR: Excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome, and it is postulate that NAFLD and alcoholic fatty Liver disease share the same pathogenesis.
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