High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
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TLDR
The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.About:
This article is published in Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 252 citations till now. The article focuses on the topics: Fructokinase & Steatohepatitis.read more
Citations
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Landslide hazard mapping, DNA damage induced by sucrose and the biotechnology potential of sponge-associated bacteria communities.
TL;DR: A new geologic strategy is invokes to evaluate potential landslide regions in Serra do Mar based on soil fractures and foliation, and the slope geometry of the area, which could improve the diagnostic of hazard in hill slope areas and directly impact the development of a framework for safe hill slope use for agricultural and urban purposes.
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Mechanisms of Fibrosis in Steatohepatitis
TL;DR: Recent data on the basic mechanisms leading to the development of fibrosis in nonalcoholic steatohepatitis are discussed, in particular those which may identify novel approaches to treatment.
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Correction: Corrigendum: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture
Manuel Hilbert,Akira Noga,Daniel Frey,Virginie Hamel,Paul Guichard,Sebastian H. W. Kraatz,Moritz Pfreundschuh,Sarah Hosner,Isabelle Flückiger,Rolf Jaussi,Mara M. Wieser,Katherine M. Thieltges,Xavier Deupi,Daniel J. Müller,Richard A. Kammerer,Pierre Gönczy,Masafumi Hirono,Michel O. Steinmetz +17 more
TL;DR: In the version of this Article originally published, Paul Guichard should not have been listed under the statement 'These authors contributed equally to this work'.
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A review of nonalcoholic fatty liver disease - genetics and animal models
TL;DR: A comprehensive NAFLD review that covers the population genetics, genome-wide associated study, epidemiology, pathophysiology of the disease progression, and current existing animal models is provided.
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Diet-induced animal models of nonalcoholic fatty liver disease
Qing-Min Zeng,Jia Li +1 more
References
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Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Xiaosen Ouyang,Pietro Cirillo,Yuri Y. Sautin,Shannon J. McCall,James L. Bruchette,Anna Mae Diehl,Richard J. Johnson,Manal F. Abdelmalek +7 more
TL;DR: The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity.
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Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
Gianfranco Pagano,Giovanni Pacini,Giovanni Musso,Roberto Gambino,Fabio Mecca,Nadia Depetris,Maurizio Cassader,Ezio David,Paolo Cavallo-Perin,Mario Rizzetto +9 more
TL;DR: Hyperinsulinemia and insulin resistance occur frequently in patients with NASH; these conditions do not stem from a reduced hepatic insulin extraction but from an enhanced pancreatic insulin secretion compensatory to reduced insulin sensitivity.
Journal ArticleDOI
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
TL;DR: Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.
Journal ArticleDOI
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
TL;DR: Excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome, and it is postulate that NAFLD and alcoholic fatty Liver disease share the same pathogenesis.
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