High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
TLDR
The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.About:
This article is published in Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 252 citations till now. The article focuses on the topics: Fructokinase & Steatohepatitis.read more
Citations
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Development of a Representative Mouse Model with Nonalcoholic Steatohepatitis
TL;DR: A NASH mouse model is described, which is based on feeding non–genetically manipulated C57BL6/J mice a ‘Western style’ high‐fat/high‐sucrose diet (HF‐HSD), which leads to early obesity, insulin resistance, and hypercholesterolemia and closely mimics the human disease.
Journal ArticleDOI
Fructose and prostate cancer: toward an integrated view of cancer cell metabolism.
Daniela V Carreño,Néstor Corro,Verónica Torres-Estay,Loreto P. Véliz,Rodrigo Jaimovich,Pedro Cisternas,Ignacio F. San Francisco,Paula Sotomayor,Marina Tanasova,Nibaldo C. Inestrosa,Alejandro Godoy,Alejandro Godoy +11 more
TL;DR: This review article summarizes what is currently known about transport and metabolism of hexoses, and more specifically fructose, in CaP and provides experimental evidences indicating that CaP cells may have increased capacity to transport and metabolize fructose in vitro and in vivo.
Journal ArticleDOI
Herbal adaptogens combined with protein fractions from bovine colostrum and hen egg yolk reduce liver TNF-α expression and protein carbonylation in Western diet feeding in rats.
C. Brooks Mobley,Ryan G. Toedebusch,Christopher M. Lockwood,Alexander J. Heese,Conan Zhu,Anna E. Krieger,Clayton L. Cruthirds,John C Hofheins,Charles E. Wiedmeyer,Dae Y Kim,Frank W. Booth,Michael D. Roberts,Michael D. Roberts +12 more
TL;DR: Bioinformatics and serum clinical safety markers and liver pathology suggest that AF prevented WD-induced alterations in select genes related to the transport and metabolism of carbohydrates in favor of select genesrelated to lipid Transport and metabolism.
Journal ArticleDOI
Fructose and fructose kinase in cancer and other pathologies
TL;DR: In this article, the authors summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHK-C and KHKA in metabolic liver diseases and their relevant metabolic disorders and cancer, and highlight the specific protein kinase activity of kHK-A in tumor development.
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Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH).
Sudaporn Pummoung,Duangporn Werawatganon,Maneerat Chayanupatkul,Naruemon Klaikeaw,Prasong Siriviriyakul +4 more
TL;DR: In this paper, the authors evaluated the effect of genistein on hepatic steatosis and apoptosis in NASH rats with OVX and non-OVX.
References
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Journal ArticleDOI
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Xiaosen Ouyang,Pietro Cirillo,Yuri Y. Sautin,Shannon J. McCall,James L. Bruchette,Anna Mae Diehl,Richard J. Johnson,Manal F. Abdelmalek +7 more
TL;DR: The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity.
Journal ArticleDOI
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
Gianfranco Pagano,Giovanni Pacini,Giovanni Musso,Roberto Gambino,Fabio Mecca,Nadia Depetris,Maurizio Cassader,Ezio David,Paolo Cavallo-Perin,Mario Rizzetto +9 more
TL;DR: Hyperinsulinemia and insulin resistance occur frequently in patients with NASH; these conditions do not stem from a reduced hepatic insulin extraction but from an enhanced pancreatic insulin secretion compensatory to reduced insulin sensitivity.
Journal ArticleDOI
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
TL;DR: Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.
Journal ArticleDOI
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
TL;DR: Excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome, and it is postulate that NAFLD and alcoholic fatty Liver disease share the same pathogenesis.
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