High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
TLDR
The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.About:
This article is published in Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 252 citations till now. The article focuses on the topics: Fructokinase & Steatohepatitis.read more
Citations
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Combination of Alcohol and Fructose Exacerbates Metabolic Imbalance in Terms of Hepatic Damage, Dyslipidemia, and Insulin Resistance in Rats
Salamah Mohammad Alwahsh,Min Xu,Frank Christian Schultze,Jörg Wilting,Sabine Mihm,Dirk Raddatz,Giuliano Ramadori +6 more
TL;DR: Evidence is provided for the coaction of ethanol and fructose with a high-fat-diet on dyslipidemia and insulin resistance-accompanied liver damage and the L-EF diet significantly elevated blood glucose, insulin, and total-cholesterol levels.
Journal ArticleDOI
Adipokines in Liver Cirrhosis.
TL;DR: The Child-Pugh score and the model of end-stage liver disease score have been established to assess residual liver function in patients with liver cirrhosis, and studies having analyzed these proteins in systemic blood in cirrhotic patients are listed to identify adipokines that are comparably changed in the different cohorts of patients.
Journal ArticleDOI
Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity
Jong Han Lee,Ligen Lin,Pingwen Xu,Kenji Saito,Qiong Wei,Adelina G. Meadows,Odelia Y.N. Bongmba,Geetali Pradhan,Hui Zheng,Yong Xu,Yuxiang Sun +10 more
TL;DR: Novel findings suggest that suppressing central ghrelin signaling may serve as a unique antiobesity strategy and that neuronal GHS-R is a crucial regulator of energy metabolism and a key mediator of DIO.
Journal ArticleDOI
Metabolic syndrome: F stands for fructose and fat
TL;DR: It emerges that mice that cannot metabolize fructose are healthier when placed on carbohydrate-rich diets.
Journal ArticleDOI
Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats
Damiana Tortolero Pierine,M. E. L. Navarro,Igor Otavio Minatel,Igor Otavio Minatel,Renata de Azevedo Melo Luvizotto,Andre F. Nascimento,Andre F. Nascimento,Ana Lúcia dos Anjos Ferreira,Kyung-Jin Yeum,Camila Renata Corrêa +9 more
TL;DR: Lycopene may be beneficial in the prevention and treatment of oxidative stress and inflammation in the kidney due to obesity.
References
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Journal ArticleDOI
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Xiaosen Ouyang,Pietro Cirillo,Yuri Y. Sautin,Shannon J. McCall,James L. Bruchette,Anna Mae Diehl,Richard J. Johnson,Manal F. Abdelmalek +7 more
TL;DR: The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity.
Journal ArticleDOI
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
Gianfranco Pagano,Giovanni Pacini,Giovanni Musso,Roberto Gambino,Fabio Mecca,Nadia Depetris,Maurizio Cassader,Ezio David,Paolo Cavallo-Perin,Mario Rizzetto +9 more
TL;DR: Hyperinsulinemia and insulin resistance occur frequently in patients with NASH; these conditions do not stem from a reduced hepatic insulin extraction but from an enhanced pancreatic insulin secretion compensatory to reduced insulin sensitivity.
Journal ArticleDOI
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
TL;DR: Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.
Journal ArticleDOI
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
TL;DR: Excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome, and it is postulate that NAFLD and alcoholic fatty Liver disease share the same pathogenesis.
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