High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
TLDR
The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.About:
This article is published in Hepatology.The article was published on 2013-11-01 and is currently open access. It has received 252 citations till now. The article focuses on the topics: Fructokinase & Steatohepatitis.read more
Citations
More filters
Journal ArticleDOI
Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy
Miguel A. Lanaspa,Takuji Ishimoto,Christina Cicerchi,Yoshifuru Tamura,Carlos A. Roncal-Jimenez,Wei Chen,Katsuyuki Tanabe,Ana Andres-Hernando,David J. Orlicky,Esteban Finol,Shinichiro Inaba,Nanxing Li,Christopher J. Rivard,Tomoki Kosugi,Laura G. Sánchez-Lozada,J. Mark Petrash,Yuri Y. Sautin,A. Ahsan Ejaz,Wataru Kitagawa,Gabriela E. Garcia,David T. Bonthron,Aruna Asipu,Christine P. Diggle,Bernardo Rodriguez-Iturbe,Takahiko Nakagawa,Takahiko Nakagawa,Richard J. Johnson +26 more
TL;DR: These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
Journal ArticleDOI
Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)
TL;DR: Understanding of how fructose intake can favor these pathological processes is crucial for the development of appropriate noninvasive diagnostic and therapeutic approaches to detect and treat these metabolic effects.
Journal ArticleDOI
Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes
TL;DR: It is suggested that fructose-induced obesity is driven by engagement of a "fat switch" and provide novel insights into new approaches for the prevention and treatment of these important diseases.
Journal ArticleDOI
PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
Themis Thoudam,Chae-Myeong Ha,Jaechan Leem,Dipanjan Chanda,Jong-Seok Park,Hyo Jeong Kim,Jae-Han Jeon,Yeon Kyung Choi,Suthat Liangpunsakul,Yang Hoon Huh,Tae-Hwan Kwon,Keun-Gyu Park,Robert A. Harris,Kyu Sang Park,Hyun-Woo Rhee,Inkyu Lee +15 more
TL;DR: It is demonstrated that PDK4 interacts with and stabilizes the IP3R1-GRP75-VDAC1 complex at the MAM interface and that forced formation and stabilization of MAMs with synthetic ER–mitochondria linker prevented the beneficial effects ofPDK4 deficiency on insulin signaling.
The Sweet Path to Metabolic Demise: Fructose and Lipid
TL;DR: It is shown that hepatic insulin resistance develops from diacylglycerol-PKCɛ-mediated impairment of insulin signaling and possibly additional mechanisms, and initiatives that decrease fructose consumption and therapies that block fructose-mediated lipogenesis will be necessary to avert future metabolic pandemics.
References
More filters
Journal ArticleDOI
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis†
TL;DR: Endoplasmic reticulum stress and related signaling networks, (adipo)cytokines, and innate immunity are emerging as central pathways that regulate key features of NASH.
Journal ArticleDOI
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Xiaosen Ouyang,Pietro Cirillo,Yuri Y. Sautin,Shannon J. McCall,James L. Bruchette,Anna Mae Diehl,Richard J. Johnson,Manal F. Abdelmalek +7 more
TL;DR: The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity.
Journal ArticleDOI
Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
Gianfranco Pagano,Giovanni Pacini,Giovanni Musso,Roberto Gambino,Fabio Mecca,Nadia Depetris,Maurizio Cassader,Ezio David,Paolo Cavallo-Perin,Mario Rizzetto +9 more
TL;DR: Hyperinsulinemia and insulin resistance occur frequently in patients with NASH; these conditions do not stem from a reduced hepatic insulin extraction but from an enhanced pancreatic insulin secretion compensatory to reduced insulin sensitivity.
Journal ArticleDOI
Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
TL;DR: Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.
Journal ArticleDOI
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome.
TL;DR: Excessive dietary fructose consumption may underlie the development of nonalcoholic fatty liver disease and the metabolic syndrome, and it is postulate that NAFLD and alcoholic fatty Liver disease share the same pathogenesis.
Related Papers (5)
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Kimber L. Stanhope,Jean-Marc Schwarz,Jean-Marc Schwarz,Nancy L. Keim,Steven C. Griffen,Andrew A. Bremer,James L. Graham,Bonnie Hatcher,Chad L. Cox,Artem Dyachenko,Wei Zhang,John P. McGahan,Anthony Seibert,Ronald M. Krauss,Sally Chiu,Ernst J. Schaefer,Masumi Ai,Seiko Otokozawa,Katsuyuki Nakajima,Katsuyuki Nakajima,Takamitsu Nakano,Carine Beysen,Marc K. Hellerstein,Lars Berglund,Peter J. Havel +24 more