Journal ArticleDOI
High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice.
Yoshiyuki Kimura,Maho Sumiyoshi +1 more
TLDR
The findings suggest that the acceleration of tumor growth and metastasis by feeding the 3 diets may be due to the increase of angiogenic factors and the reduction of antiangiogenic Factors.Abstract:
Epidemiological studies indicate that the risk factors for the development of various cancers are closely associated with metabolic symptoms such as obesity, hyperlipidemia, and insulin resistance caused by the excess consumption of high-calorie diets. However, the mechanisms of tumor growth and metastasis caused by feeding a high-calorie diet have not been clarified yet in tumor-bearing mice. In this study, we examined the effects of a high-fat (HF), a high-sucrose (HS), a high-cholesterol (HC) or a low-fat/low-sucrose (LF/LS) diet on tumor growth and metastasis in tumor-bearing mice. Angiogenic factors such as plasma leptin and monocyte chemoattractant protein-1 (MCP-1) were increased after the implantation of tumors, whereas conversely, an antiangiogenic factor, adiponectin, was reduced after the implantation of tumors in mice fed the HF, the HS, or the HC diet compared to LF/LS diet. Furthermore, we found that vascular endothelial growth factor, hypoxia inducible factor-1alpha and MCP-1 expression levels in tumors of mice fed the HF, the HS, or the HC diet were increased compared to those of mice fed the LF/LS diet. These findings suggest that the acceleration of tumor growth and metastasis by feeding the 3 diets may be due to the increase of angiogenic factors and the reduction of antiangiogenic factors.read more
Citations
More filters
Journal ArticleDOI
A Western-Type Diet Accelerates Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer
Gemma Llaverias,Christiane Danilo,Yu Wang,Agnes Witkiewicz,Kristin M. Daumer,Michael P. Lisanti,Philippe G. Frank +6 more
TL;DR: Consumption of a Western-type diet--that is, enriched in both fat and cholesterol--accelerated prostate tumor incidence and tumor burden compared to mice fed a control chow diet and shows that this diet increased the extent and the histological grade of prostate tumors.
Journal ArticleDOI
Serum lipid profiles and cancer risk in the context of obesity: four meta-analyses.
Jennifer C. Melvin,Jennifer C. Melvin,Lars Holmberg,Lars Holmberg,Lars Holmberg,Sabine Rohrmann,Massimo Loda,Mieke Van Hemelrijck +7 more
TL;DR: Low levels of TC and TG, as well as low levels of HDL and ApoA-I, were consistently associated with increased risk of obesity-related cancers, but modest RRs suggest serum lipids to be associated with the risk of cancer.
Journal ArticleDOI
Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis.
Truman M. Earl,Ian B. Nicoud,Janene Pierce,J. P. Wright,N. E. Majoras,J. E. Rubin,K. P. Pierre,D. L. Gorden,Ravi S. Chari,Ravi S. Chari +9 more
TL;DR: It is demonstrated that steatotic livers have increased susceptibility to metastatic tumor growth and that silencing tumor cell TLR4 reduces metastatic tumors burden in Steatotic liver.
Journal ArticleDOI
Lipid metabolism in cancer progression and therapeutic strategies
Yan Fu,Tiantian Zou,Xiao-Tian Shen,Peter J. Nelson,Jiahui Li,Chao Wu,Jimeng Yang,Yan Zheng,Christiane Bruns,Yue Zhao,Lun-Xiu Qin,Qiongzhu Dong +11 more
TL;DR: Recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression is reviewed, the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer are discussed.
Journal ArticleDOI
Obesity and Cancer: An Angiogenic and Inflammatory Link
TL;DR: How the dysfunctional angiogenesis and inflammation occurring in adipose tissue in obesity may promote tumor progression, resistance to chemotherapy, and targeted therapies such as anti‐angiogenic and immune therapies are discussed.
References
More filters
Journal ArticleDOI
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.
TL;DR: Current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women, and increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.
Journal ArticleDOI
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Journal ArticleDOI
Biological Action of Leptin as an Angiogenic Factor
M. Rocio Sierra-Honigmann,Anjali K. Nath,Chiaki Murakami,Guillermo García-Cardeña,Andreas Papapetropoulos,William C. Sessa,Lisa A. Madge,Jeffrey S. Schechner,Michael B. Schwabb,Peter J. Polverini,Jaime Flores-Riveros +10 more
TL;DR: It is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial cells, indicating that the vascular endothelium is a target for leptin and suggesting a physiological mechanism whereby leptin-induced angiogenesis may facilitate increased energy expenditure.