Journal ArticleDOI
Histopathology of early and late human hepatic allograft rejection: Evidence of progressive destruction of interlobular bile ducts
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TLDR
It is concluded that the dominant histopathological feature of hepatic allograft rejection is progressive, nonsuppurative destructive cholangitis, culminating in the disappearance of interlobular bile ducts.About:
This article is published in Hepatology.The article was published on 1985-11-01. It has received 122 citations till now. The article focuses on the topics: Interlobular bile ducts & Bile duct.read more
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Journal ArticleDOI
Banff Schema for Grading Liver Allograft Rejection: An International Consensus Document
Anthony J. Demetris,Kenneth P. Batts,Amar P. Dhillon,Linda D. Ferrell,John J. Fung,Stephen A. Geller,John Hart,Pekka Hayry,Walter J. Hofmann,Stephan Hubscher,Josef Kemnitz,George Koukoulis,Randall G. Lee,Klaus J. Lewin,Jurgen Ludwig,R. S. Markin,Lidija M. Petrovic,M. James Phillips,Bernard C. Portmann,Jorge Rakela,Parmjeet Randhawa,Finn P. Reinholt,Michel Reynés,Marie E. Robert,Hans Schlitt,Kim Solez,Dale Snover,Eero Taskinen,Swan N. Thung,G. Weldon Tillery,Russell H. Wiesner,Derek G. D. Wight,James W. Williams,Hirohiko Yamabe +33 more
TL;DR: A panel of recognized experts in liver transplantation pathology, hepatology, and surgery agreed on a common nomenclature and a set of histopathological criteria for the grading of acute liver allograft rejection, and a preferred method of reporting.
Journal ArticleDOI
Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel.
Anthony J. Demetris,David H. Adams,Christopher Bellamy,Karin Blakolmer,Andrew D. Clouston,Amar P. Dhillon,John J. Fung,Annette S. H. Gouw,Bengt Gustafsson,Hironori Haga,David J. Harrison,John Hart,Stefan G. Hubscher,R. Jaffe,Urmila Khettry,Charles Lassman,Klaus J. Lewin,Olivia M. Martinez,Yuichi Nakazawa,Desley Neil,Orit Pappo,Maria Parizhskaya,Parmjeet Randhawa,Susanne Rasoul-Rockenschaub,Finn Reinholt,Michel Reynes,Marie E. Robert,Athanassios C. Tsamandas,Ian R. Wanless,Russell H. Wiesner,Annika Wernerson,Fritz Wrba,Judy Wyatt,Hirohiko Yamabe +33 more
Journal ArticleDOI
The human cytomegalovirus.
TL;DR: Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause of birth defects, as well as an important pathogen for immunocompromised individuals and contributes to graft loss independently from graft rejection.
Journal ArticleDOI
Cytomegalovirus infection and donor/recipient hla antigens: interdependent co-factors in pathogenesis of vanishing bileduct syndrome after liver transplantation
J.G. O'Grady,Sheena Sutherland,Felicity Harvey,R. Y. Calne,GraemeJ.M. Alexander,P.T. Donaldson,Bernard Portmann,Roger Williams +7 more
TL;DR: The association between VBDS and active CMV infection was not a consequence of alterations in immunosuppressive therapy and the findings would be consistent with precipitation of chronic rejection by CMV-induced HLA antigen expression in patients rendered susceptible by the donor/recipient Hla antigen match.
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Apoptosis and hepatobiliary disease
Tushar Patel,Gregory J. Gores +1 more
TL;DR: Subsequent investigation into defining the cellular regulatory mechanisms and biochemical processes involved will be fertile ground for future research that may ultimately lead to novel therapeutic approaches for autoimmune diseases, malignancies, and viral disease.
References
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Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 seattle patients
Howard M. Shulman,Keith M. Sullivan,Paul L. Weiden,George B. McDonald,Gary E. Striker,George E. Sale,Robert C. Hackman,Tsoi Ms,Rainer Storb,E. Donnall Thomas +9 more
TL;DR: Three patients had limited chronic GVHD with relatively favorable prognosis characterized by localized skin involvement and/or hepatic disease without chronic aggressive histology, but most patients, however, had extensive disease with a progressive course.
Journal ArticleDOI
Role of aberrant hla-dr expression and antigen presentation in induction of endocrine autoimmunity
TL;DR: This mechanism of autoimmune disease induction explains vague associations with viral infections and long latency periods before disease becomes manifest and gives a simple explanation for the well-documented association between HLA-DR and autoimmune diseases in man.
Journal ArticleDOI
Evolution of Liver Transplantation
Thomas E. Starzl,Shunzaburo Iwatsuki,David H. Van Thiel,J. Carlton Gartner,Basil J. Zitelli,J. Jeffrey Malatack,Robert R. Schade,Shaw Jr . Byers W.,Thomas R. Hakala,J. Thomas Rosenthal,Kendrick A. Porter +10 more
TL;DR: This work aims to provide a clear picture of the immune system’s role in the development of central giant cell granuloma and the role that these cells play in the progression of disease.
Journal Article
Recombinant interferon-gamma increases HLA-DR synthesis and expression.
TL;DR: It is reported here that recombinant interferon-gamma (IFN-Gamma) increases the synthesis and expression of the HLA-DR (la-like) antigens as well as beta 2-microglobulin (beta 2-m), a low m.w. subunit of HLA, on human melanoma cells.
Journal ArticleDOI
Aberrant expression of HLA-DR antigens on bileduct epithelium in primary biliary cirrhosis: relevance to pathogenesis.
TL;DR: The increased HLA-A,B,C, expression may be a means of amplifying T-cell cytotoxic responses in PBC and enables these cells to present "self antigens" to sensitised T-lymphocytes and to promote autorecognition.