Journal ArticleDOI
Human milk: a source of more life than we imagine
Prescilla V. Jeurink,J. van Bergenhenegouwen,E. Jiménez,Léon M.J. Knippels,Leónides Fernández,Johan Garssen,Jan Knol,Juan M. Rodríguez,Rosario Martín +8 more
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TLDR
A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and lactation.Abstract:
The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more sophisticated culture-dependent and -independent techniques, and the steady development of the -omic approaches are opening up the new concept of the ‘milk microbiome’, a complex ecosystem with a greater diversity than previously anticipated. In this review, possible mechanisms by which bacteria can reach the mammary gland (contamination versus active migration) are discussed. In addition, the potential roles of human milk for both infant and maternal health are summarised. A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and ...read more
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The microbiota of the respiratory tract: gatekeeper to respiratory health
Wing Ho Man,Wouter A. A. de Steenhuijsen Piters,Wouter A. A. de Steenhuijsen Piters,Debby Bogaert,Debby Bogaert +4 more
TL;DR: The epidemiological, biological and functional evidence that support the physiological role of the respiratory microbiota in the maintenance of human health are discussed.
Journal ArticleDOI
The infant microbiome development: mom matters
Noel T. Mueller,Elizabeth Bakacs,Joan Combellick,Zoya Grigoryan,Maria Gloria Dominguez-Bello +4 more
TL;DR: Recent knowledge about the impacts on infant microbiome assembly is reviewed, preventive and restorative strategies to ameliorate the effects of these impacts are discussed, and where research is needed to advance this field and improve the health of future generations are highlighted.
Journal ArticleDOI
Next-generation beneficial microbes : The case of Akkermansia muciniphila
TL;DR: It is proposed that microbes and microbiomegnosy, or knowledge of the authors' gut microbiome, can become a novel source of future therapies as plants and its related knowledge have been the source for designing drugs over the last century.
Journal ArticleDOI
Microbial Changes during Pregnancy, Birth, and Infancy.
TL;DR: The main factors shaping the infant microbiome—modes of delivery, feeding, weaning, and exposure to antibiotics are reviewed, starting to build a broader understanding of healthy vs. abnormal microbial alterations throughout major developmental time-points.
Journal ArticleDOI
Development of the gut microbiota in infancy and its impact on health in later life.
Masaru Tanaka,Jiro Nakayama +1 more
TL;DR: Recent findings regarding gut microbiota establishment are summarized, including the importance of various factors related to the development of the immune system and allergic diseases later in life are summarized.
References
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Journal ArticleDOI
Milk-Derived Transforming Growth Factor-β and the Infant Immune Response
TL;DR: The data on supplementation of formula with rTGF-beta2 will be discussed and the influence of early introduction of oral beta-lactoglobulin in allergy prone rat pups will also be discussed.
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Analysis of DNA restriction fragment length polymorphism extends the evidence for breast milk transmission in Streptococcus agalactiae late-onset neonatal infection.
Edouard Bingen,Erick Denamur,Lambert-Zechovsky N,Y. Aujard,Nalma Brahimi,Pierre Geslin,Jacques Elion +6 more
TL;DR: Analysis of restriction fragment length polymorphism of total DNA and of ribosomal DNA (ribotyping) was used to document four cases of Streptococcus agalactiae mother-to-infant transmission potentially associated with ingestion of infected mother's milk, extending the evidence for breast milk transmission in S. agalACTiae late-onset neonatal infection.
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Relationship between the resistance to bile salts and low pH with exopolysaccharide (EPS) production of Bifidobacterium spp. isolated from infants feces and breast milk
Gulcin Alp,Belma Aslim +1 more
TL;DR: This investigation showed that high EPS production of Bifidobacteria may be important in the selection of probiotic strains for resistance to bile salts and low pH.
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Occurrence of oligosaccharides in feces of breast-fed babies in their first six months of life and the corresponding breast milk.
Simone Albrecht,Henk A. Schols,Ellen G. H. M. van den Heuvel,Alphons G. J. Voragen,Harry Gruppen +4 more
TL;DR: Eleven of these 'hybrid'-oligosaccharides were annotated in this study and pointed to a gastrointestinal degradation of the feeding-related HMOs, followed by conjugation with blood group specific antigenic determinants present in the gastrointestinal mucus layer.
Journal ArticleDOI
Are There Naturally Occurring Pleomorphic Bacteria in the Blood of Healthy Humans
Richard W. McLaughlin,Hojatollah Vali,Peter C. K. Lau,Roger G. E. Palfree,Angela De Ciccio,Marc Sirois,Darakhshan Ahmad,Richard Villemur,Marcel Desrosiers,E. C. S. Chan +9 more
TL;DR: Dark-field microscopy of blood from healthy individuals revealed the existence of pleomorphic microorganisms that exhibited limited growth and susceptibility to antibiotics and could be detected by fluorescent in situ hybridization and flow cytometry.